How can we measure insulin sensitivity/resistance?

被引:182
作者
Antuna-Puente, B. [1 ]
Disse, E. [2 ,3 ,4 ,5 ,6 ,7 ]
Rabasa-Lhoret, R. [8 ,9 ,10 ]
Laville, M. [2 ,3 ,4 ,5 ,6 ,7 ]
Capeau, J. [1 ,11 ,12 ]
Bastard, J. -P. [1 ,11 ,12 ]
机构
[1] Univ Paris 06, INSERM, Ctr Rech St Antoine, UMR S938, F-75571 Paris 12, France
[2] Univ Lyon, Ctr Rech Nutr Humaine Rhone Alpes, F-69003 Lyon, France
[3] INSERM, U870, IFR62, F-69008 Lyon, France
[4] INRA, UMR1235, F-69008 Lyon, France
[5] INSA, RMND, F-69621 Villeurbanne, France
[6] Univ Lyon 1, Fac Med R Laennec, F-69003 Lyon, France
[7] Hop Edouard Herriot, Hosp Civils Lyon, F-69008 Lyon, France
[8] Univ Montreal, Dept Nutr, Montreal, PQ H3C 3J7, Canada
[9] IRCM, Montreal, PQ, Canada
[10] Univ Montreal, Ctr Hosp, MDRC, Montreal, PQ, Canada
[11] Hop Tenon, AP HP, Serv Biochim & Hormonol, F-75020 Paris, France
[12] Ctr Rech Nutr Humaine, F-75013 Paris, France
关键词
Hyperinsulinaemic-euglycaemic glucose clamp; Insulin sensitivity; Insulin resistance; HOMA; QUICKI; OGTT; Review; GLUCOSE-TOLERANCE TEST; HOMEOSTASIS MODEL ASSESSMENT; HYPERINSULINEMIC-EUGLYCEMIC CLAMP; CARDIOVASCULAR RISK-FACTORS; OBESE POSTMENOPAUSAL WOMEN; CHECK INDEX; MINIMAL MODEL; DIABETES-MELLITUS; INTRAVENOUS GLUCOSE; CLINICAL-PRACTICE;
D O I
10.1016/j.diabet.2011.01.002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Insulin resistance represents a major public health problem, as it plays a major role in the pathophysiology of type 2 diabetes mellitus; it is also associated with increased cardiovascular risk and atherogenic dyslipidaemia, and is a central component of the cluster of metabolic abnormalities that comprise the metabolic syndrome. Thus, the development of tools to quantify insulin sensitivity/resistance has been the main objective of a number of studies. Insulin resistance can be estimated with the use of several biological measurements that evaluate different aspects of this complex situation. To that end, it requires various resources, ranging from just a single fasting blood sample for simple indices, such as the HOMA or QUICKI, to a research setting in which to perform the gold-standard hyperinsulinaemic-euglycaemic clamp test. The choice of method for evaluating insulin resistance depends on the nature of the information required (classification of individual subjects, group comparisons, precise measurement of either global, muscle or liver insulin sensitivity/resistance) and on the available resources. The aim of this review is to analyze the most frequently used assay methods in an attempt to evaluate when and why these methods may be useful. (C) 2011 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:179 / 188
页数:10
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