New jaspamnide derivatives from the marine sponge Jaspis splendans collected in Vanuatu

被引：52

作者：

Zampella, A

Giannini, C

Debitus, C

Roussakis, C

D'Auria, MV

机构：

[1] Univ Naples, Dipartimento Chim Sostanze Natural, I-80131 Naples, Italy

[2] Univ Nantes, ISOMER, Fac Pharm, F-44035 Nantes 01, France

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 02期

关键词：

D O I：

10.1021/np9803225

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new jaspamide derivatives (1 and 2) along with jaspamide have been isolated from the marine sponge Jaspis splendans collected in Vanuatu. Their chemical structures were determined from 1D and 2D NMR studies and MS data. These two compounds inhibited the in vitro growth of the NSCLC-NG human tumor cell Lines with IC50 values in the mu g/mL range.

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页码：332 / 334

页数：3

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