Elevation of interleukin 6 levels in patients with chronic hepatitis due to hepatitis C virus

被引：82

作者：

Malaguarnera, M

DiFazio, I

Romeo, MA

Restuccia, S

Laurino, A

Trovato, BA

机构：

[1] Dept. of Int. Med. and Geriatrics, University of Catania, 829-95126 Catania, P.O. Cannizzaro via Messina

来源：

JOURNAL OF GASTROENTEROLOGY | 1997年 / 32卷 / 02期

关键词：

cytokines; interleukin 6 (IL-6); hepatitis C virus (HCV); chronic hepatitis; histological activity index (HAI);

D O I：

10.1007/BF02936370

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Interleukin 6 (IL-6) is a pleiotropic cytokine produced by a wide variety of lymphoid and nonlymphoid tissues. We studied the relationship between IL-6 and the liver in an attempt to elucidate this cytokine's role in hepatitis C-induced liver inflammation. We investigated the behavior of serum IL-6 in 25 patients with chronic hepatitis C (divided into three groups depending on severity) and in 27 healthy controls. Our results showed a significant elevation (P < 0.0001) in serum IL-6 levels in the patients with chronic hepatitis C, correlated with the histological activity index (HAI) and their HCV-RNA serum levels. This rise may represent the expression of the hepatitis C virus-induced inflammatory state.

引用

页码：211 / 215

页数：5

共 20 条

[1]

ANDUS T, 1991, HEPATOLOGY, V13, P364, DOI 10.1016/0270-9139(91)92454-G

[2] ABSOLUTE MESSENGER-RNA QUANTIFICATION USING THE POLYMERASE CHAIN-REACTION (PCR) - A NOVEL-APPROACH BY A PCR AIDED TRANSCRIPT TITRATION ASSAY (PATTY) [J].

BECKERANDRE, M ;

HAHLBROCK, K .

NUCLEIC ACIDS RESEARCH, 1989, 17 (22) :9437-9446

[3]

BOWCOCK A M, 1988, Genomics, V3, P8, DOI 10.1016/0888-7543(88)90152-8

[4]

BUSAM KJ, 1990, J HEPATOL, V11, P376

[5]

DESMET VJ, 1994, HEPATOLOGY, V19, P1513, DOI 10.1002/hep.1840190629

[6]

EMILIE D, 1992, LIVER, V12, P34

[7] CHARACTERIZATION OF INTERLEUKIN-1 AND INTERLEUKIN-6 PRODUCTION BY HEPATIC ENDOTHELIAL-CELLS AND MACROPHAGES [J].

FEDER, LS ;

TODARO, JA ;

LASKIN, DL .

JOURNAL OF LEUKOCYTE BIOLOGY, 1993, 53 (02) :126-132

[8] INTERFERON BETA-2/B-CELL STIMULATORY FACTOR TYPE-2 SHARES IDENTITY WITH MONOCYTE-DERIVED HEPATOCYTE-STIMULATING FACTOR AND REGULATES THE MAJOR ACUTE PHASE PROTEIN RESPONSE IN LIVER-CELLS [J].

GAULDIE, J ;

RICHARDS, C ;

HARNISH, D ;

LANSDORP, P ;

BAUMANN, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (20) :7251-7255

[9] QUANTITATION OF HEPATITIS-C VIRUS-RNA IN SERUM OF ASYMPTOMATIC BLOOD-DONORS AND PATIENTS WITH TYPE-C CHRONIC LIVER-DISEASE [J].

HAGIWARA, H ;

HAYASHI, N ;

MITA, E ;

NAITO, M ;

KASAHARA, A ;

FUSAMOTO, H ;

KAMADA, T .

HEPATOLOGY, 1993, 17 (04) :545-550

[10] QUANTITATIVE-ANALYSIS OF HEPATITIS-C VIRUS-RNA IN SERUM DURING INTERFERON ALFA THERAPY [J].

HAGIWARA, H ;

HAYASHI, N ;

MITA, E ;

TAKEHARA, T ;

KASAHARA, A ;

FUSAMOTO, H ;

KAMADA, T .

GASTROENTEROLOGY, 1993, 104 (03) :877-883

← 1 2 →