Altered white matter integrity in young adults with first-episode, treatment-naive, and treatment-responsive depression

被引：78

作者：

Guo, Wen-bin ^{[2
,3
]}

Liu, Feng ^{[1
]}

Xue, Zhi-min ^{[2
]}

Gao, Keming ^{[4
]}

Wu, Ren-rong ^{[2
]}

Ma, Chao-qiong ^{[1
]}

Liu, Zhe-ning ^{[2
]}

Xiao, Chang-qing ^{[3
]}

Chen, Hua-fu ^{[1
]}

Zhao, Jing-ping ^{[2
,5
]}

机构：

[1] Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab Neuroinformat, Chengdu 610054, Sichuan, Peoples R China

[2] Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China

[3] Guangxi Med Univ, Affiliated Hosp 1, Mental Hlth Ctr, Nanning 530021, Guangxi, Peoples R China

[4] Case Western Reserve Univ, Sch Med, Mood & Anxiety Clin,Univ Hosp Case Med Ctr, Mood Disorders Program,Dept Psychiat, Cleveland, OH 44106 USA

[5] Hangzhou Seventh People Hosp, Hangzhou 310001, Zhejiang, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2012年 / 522卷 / 02期

关键词：

Major depressive disorder; Diffusion tensor imaging; Tract-based spatial statistics; White matter; LATE-LIFE DEPRESSION; TREATMENT-RESISTANT; VOXELWISE ANALYSIS; DISORDER;

D O I：

10.1016/j.neulet.2012.06.027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Abnormalities of the white matter (WM) tracts integrity in brain areas involved in emotional regulation have been postulated in major depressive disorder (MDD). However, there is no diffusion tensor imaging (DTI) study in patients with treatment-responsive MDD at present. DTI scans were performed on 22 patients with treatment-responsive MDD and 19 well-matched healthy subjects. Tract-based spatial statistics (TBSS) approach was employed to analyze the scans. Voxel-wise statistics revealed four brain WM tracts with lower fractional anisotropy (FA) in patients compared to healthy subjects: the bilateral internal capsule, the genu of corpus callosum, the bilateral anterior corona radiata, and the right external capsule. FA values were nowhere higher in patients compared to healthy subjects. Our findings demonstrate that the abnormalities of the WM tracts, major in the projection fibers and corpus callosum, may contribute to the pathogenesis of treatment-responsive MDD. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：139 / 144

页数：6

共 24 条

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