Association of low serum levels of apolipoprotein A-I with adverse outcomes in patients with nonischemic heart failure

被引：54

作者：

Iwaoka, Masahiko ^{[1
]}

Obata, Jyun-Ei ^{[1
]}

Abe, Makoto ^{[1
]}

Nakamura, Takamitsu ^{[1
]}

Kitta, Yoshinobu ^{[1
]}

Kodama, Yasushi ^{[1
]}

Kawabata, Ken-Ichi ^{[1
]}

Takano, Hajime ^{[1
]}

Fujioka, Daisuke ^{[1
]}

Saito, Yukio ^{[1
]}

Kobayashi, Tsuyoshi ^{[1
]}

Hasebe, Hideyuki ^{[1
]}

Kugiyama, Kiyotaka ^{[1
]}

机构：

[1] Univ Yamanashi, Dept Internal Med 2, Fac Med, Interdisciplinary Grad Sch Med & Engn,Chuo Ku, Yamanashi 4093898, Japan

来源：

JOURNAL OF CARDIAC FAILURE | 2007年 / 13卷 / 04期

关键词：

apolipoprotein A-I; high-density lipoprotein; heart failure; inflammation;

D O I：

10.1016/j.cardfail.2007.01.007

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Background: There is extensive evidence that low serum levels of high-density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apoA-I) predict a worse prognosis in patients with ischemic heart disease. This study examined whether apoA-I levels may also provide prognostic information in patients with nonischemic heart failure. Methods and Results: A prospective follow-up study was performed in 117 consecutive patients with nonischemic heart failure for a period of <= 36 months until the first occurrence of l of the following clinical events: all-cause death, cardiac death, and hospitalization with worsening heart failure. Serum levels of apoA-I were measured by immunoturbidimetry. A clinical event occurred during follow-up in 28 (24%) patients. A multivariate Cox proportional hazards analysis showed that lower apoA-I levels (<103 mg/dL: determined by a receiver-operating characteristic analysis) were significantly associated with an adverse outcome that was independent of creatinine clearance, HDL cholesterol levels, and brain natriuretic peptide levels. ApoA-I was inversely correlated with levels of C-reactive protein and fibrinogen, known inflammatory predictors of poor prognosis in heart failure. Conclusions: Low levels of apoA-I are independently associated with an adverse prognosis in patients with nonischemic heart failure. ApoA-I may play a beneficial role in nonischemic heart failure partly through an anti-inflammatory action.

引用

页码：247 / 253

页数：7

共 21 条

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