Detection of perfluorocarbons in blood by headspace solid-phase microextraction combined with gas chromatography/mass spectrometry

被引：17

作者：

Mathurin, JC

de Ceaurriz, J

Audran, M

Krafft, MP

机构：

[1] CREPS, Lab Natl Depistage Dopage, F-92290 Chatenay Malabry, France

[2] Fac Pharm Montpellier, Dept Biophys, F-34060 Montpellier, France

[3] Inst Charles Sadron, CNRS, F-67083 Strasbourg, France

来源：

BIOMEDICAL CHROMATOGRAPHY | 2001年 / 15卷 / 07期

关键词：

D O I：

10.1002/bmc.79.abs

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A new method of detection of perfluorocarbon molecules (PFCs) in blood sample has been established. After an extraction and pre-concentration step performed by headspace solid-phase microextraction (HS-SPME), the PFCs are detected by gas chromatography-mass spectrometry (GC/MS) with an ion trap mass spectrometer in MS and MS/MS modes. The influence of different parameters on the SPME process is discussed. The limit of detection and the linearity of the procedure have been determined for two PFCs. Copyright (C) 2001 John Wiley & Sons, Ltd.

引用

页码：443 / 451

页数：9

共 19 条

[1] Solid-phase microextraction and gas chromatography-mass spectrometry for determination of monoaromatic hydrocarbons in blood and urine: Application to people exposed to air pollutants [J].