Sleep during proportional-assist ventilation with load-adjustable gain factors in critically ill patients

Background: Proportional-assist ventilation with load-adjustable gain factors (PAV+) automatically adjusts the flow and volume assist to represent constant fractions of resistance and elastance of the respiratory system, respectively. Resistance and elastance are calculated at random intervals of 4-10 breaths, by applying a 300ms pause maneuver at the end of selected inspirations. Objectives: To determine whether the large number of end-inspiratory occlusions during PAV+ operation influences sleep quality in critically ill patients who exhibited good patient-ventilator synchrony during pressure support (PS, baseline). Method: One and two nights' polysomnography was performed in sedated (protocol A, n=11) and non-sedated (protocol B, n=9) patients, respectively, while respiratory variables were continuously recorded. In each protocol the patients were ventilated with PAV+ and PS at two levels of assist (baseline and high). Result: In both protocols sleep quality did not differ between the modes of support or the assist levels. In sedated patients sleep efficiency was slightly but significantly higher with PAV+ than with high PS, while it did not differ between modes in non-sedated patients. The two modes of support had comparable effects on respiratory variables. Independent of the mode of support and particularly at high assist, a significant proportion of patients developed periodic breathing during sleep (27% in protocol A and 44% in protocol B). Conclusion: In patients exhibiting good patient-ventilator synchrony during PS, the large number of short-term end-inspiratory occlusions with PAV+ operation did not adversely influence sleep quality. With both modes high assist may cause unstable breathing during sleep.