Valproate enhances N-cadherin production in Xenopus embryos

被引：2

作者：

Briner, W ^{[1
]}

Papadopoulos, FC

机构：

[1] Univ Nebraska, Dept Psychol, Kearney, NE 68849 USA

[2] Univ Athens, Sch Med, GR-11527 Athens, Greece

来源：

NEUROTOXICOLOGY AND TERATOLOGY | 2000年 / 22卷 / 05期

关键词：

valproate; N-cadherin; Xenopus laevis;

D O I：

10.1016/S0892-0362(00)00086-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Xenopus embryos were exposed to valproate (0, 20, 40, 80 mg/l) either before or after neural tube closure. The embryos were then homogenized and fractionated by gel electrophoresis, and N-cadherin was detected and measured with quantitative immunoblotting. Findings indicated that valproate exposure increased N-cadherin production in a dose-dependent manner. Embryos exposed prior to neural tube closure tended to be more sensitive to the effects of valproate. These findings suggest that alterations in N-cadherin-mediated adhesion or morphogenesis may partially explain the teratogenic mechanism of valproate. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：761 / 764

页数：4

共 41 条

[1] Cell proliferation, migration and CAM-dependent neurite outgrowth as developmental in vitro endpoints for screening teratogenic potential: Application to valproic acid and related analogues of varying potency [J].