Association of syncytium-inducing phenotype of HIV-1 with CD4 cell count, viral load and sociodemographic characteristics

被引:18
作者
Furrer, H
Wendland, T
Minder, C
Christen, A
von Overbeck, J
Grunow, R
Pichler, W
Malinverni, RP
机构
[1] Univ Bern, Med Poliklin, AIDS Unit, CH-3010 Berne, Switzerland
[2] Univ Bern, Inst Clin Immunol, Berne, Switzerland
[3] Univ Bern, Inst Social & Prevent Med, Berne, Switzerland
关键词
HIV; phenotype; plasma HIV RNA; CD4+ lymphocytes; transmission category; sociodemographic characteristics;
D O I
10.1097/00002030-199811000-00016
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objectives: To study whether syncytium-inducing (Sl)/non-SI (NSI) phenotype of HIV-1 is associated with CD4+ lymphocyte count, plasma HIV RNA level, clinical stage and sociodemographic characteristics in antiretroviral-naive HIV-1-infected patients. Design: Cross-sectional analysis of single centre cohort study data. Methods: SI/NSI phenotype was determined using a cocultivation assay using patients' peripheral blood mononuclear cells and MT2 cells. Standard procedures were used for CD4+ cell counts and viral load measurements in plasma. Univariate and multivariate analyses of association of CD4+ cell counts, viral load, clinical stage, age, sex and mode of HIV transmission were performed. Results: In univariate analysis, SI phenotype was significantly associated with lower CD4+ cell counts, higher HIV RNA plasma levels, symptomatic HIV disease, male sex and age 32-36 years (middle tercile). In multivariate analysis, only lower CD4+ cell counts were associated with SI phenotype (odds ratio per increase of 100 x 10(6)/l, 0.54; 95% confidence interval, 0.38-0.78). Conclusions: HIV-1 SI phenotype was associated with lower CD4+ cell counts but not with higher plasma viral load, clinical stage or sociodemographic variables. (C) 1998 Lippincoit-Raven Publishers.
引用
收藏
页码:1341 / 1346
页数:6
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