Long-term evolution of excitotoxic cortical dysgenesis induced in the developing rat brain

被引：34

作者：

Redecker, C

Hagemann, G

Witte, OW

Marret, S

Evrard, P

Gressens, P

机构：

[1] Univ Dusseldorf, Neurol Klin, D-40225 Dusseldorf, Germany

[2] Hop Robert Debre, Serv Neurol Pediat, F-75019 Paris, France

[3] Hop Robert Debre, INSERM, CRI 97 01, F-75019 Paris, France

[4] Fac Xavier Bichat, F-75019 Paris, France

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1998年 / 109卷 / 01期

关键词：

cortical dysgenesis; ectopia; excitotoxicity; ibotenate; migration; microgyrus;

D O I：

10.1016/S0165-3806(98)00065-0

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cortical dysplasias are frequently caused by excitotoxic brain damage due to hypoxia or ischemia during development. Ibotenate, a glutamatergic agonist, was injected in the neopallium of rat pups at day of birth. The resulting cytoarchitectonic pattern includes neuronal depopulation in deep cortical layers, sulcus formation, and molecular ectopias, mimicking human polymicrogyria and disorders of neuronal migration. These cortical dysplasias persist until adulthood, providing a rat model to investigate the long-term functional consequences of cortical malformations. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：109 / 113

页数：5

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