A mild and efficient one-pot synthesis of 2-dihydroimidazoles from aldehydes

被引：123

作者：

Fujioka, H ^{[1
]}

Murai, K ^{[1
]}

Ohba, Y ^{[1
]}

Hiramatsu, A ^{[1
]}

Kita, Y ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 13期

关键词：

dihydroimidazole; aldehyde; 1,2-diamine; N; N-Acetal; N-halosuccinimide; mild reaction;

D O I：

10.1016/j.tetlet.2005.02.025

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reactions of various aldehydes and 1,2-diamines followed by NXS treatment proceed at 0 degrees C to give the corresponding dihydroimidazoles in high yields. The reaction is mild, and many functional groups such as halogens, nitrites, and esters can exist. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2197 / 2199

页数：3

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