Functions of phospholipid flippases

被引：78

作者：

Tanaka, Kazuma ^{[1
]}

Fujimura-Kamada, Konomi ^{[1
]}

Yamamoto, Takaharu ^{[1
]}

机构：

[1] Hokkaido Univ, Div Mol Interact, Inst Med Genet, Kita Ku, Sapporo, Hokkaido 0600815, Japan

来源：

JOURNAL OF BIOCHEMISTRY | 2011年 / 149卷 / 02期

基金：

日本学术振兴会;

关键词：

Cdc50; flippase; phospholipid asymmetry; P-type ATPase; vesicle transport; P-TYPE ATPASE; YEAST PLASMA-MEMBRANE; INTRAHEPATIC CHOLESTASIS TYPE-1; CHROMAFFIN GRANULE MEMBRANES; EXCHANGE FACTORS GEA1P; SACCHAROMYCES-CEREVISIAE; AMINOPHOSPHOLIPID TRANSLOCASE; ENDOPLASMIC-RETICULUM; RETROGRADE TRANSPORT; CANALICULAR MEMBRANE;

D O I：

10.1093/jb/mvq140

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Asymmetrical distribution of phospholipids is generally observed in the eukaryotic plasma membrane. Maintenance and changes of this phospholipid asymmetry are regulated by ATP-driven phospholipid translocases. Accumulating evidence indicates that type 4 P-type ATPases (P4-ATPases, also called flippases) translocate phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of the plasma membrane and internal membranes. Among P-type ATPases, P4-ATPases are unique in that they are associated with a conserved membrane protein of the Cdc50 family as a non-catalytic subunit. Recent studies indicate that flippases are involved in various cellular functions, including transport vesicle formation and cell polarity. In this review, we will focus on the functional aspect of phospholipid flippases.

引用

页码：131 / 143

页数：13

共 91 条

[1]

Loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles [J].

Alder-Baerens, N ;

Lisman, Q ;

Luong, L ;

Pomorski, T ;

Holthuis, JCM .

MOLECULAR BIOLOGY OF THE CELL, 2006, 17 (04) :1632-1642

[2]

Mutational analysis of the conserved TGES loop of sarcoplasmic reticulum Ca2+-ATPase [J].

Anthonisen, Anne Nyholm ;

Clausen, Johannes D. ;

Andersen, Jens Peter .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (42) :31572-31582

[3]

Oligomeric Dop1p is Part of the Endosomal Neo1p-Ysl2p-Arl1p Membrane Remodeling Complex [J].

Barbosa, Sonia ;

Pratte, Dagmar ;

Schwarz, Heinz ;

Pipkorn, Ruediger ;

Singer-Krueger, Birgit .

TRAFFIC, 2010, 11 (08) :1092-1106

[4]

Membrane curvature induced by Arf1-GTP is essential for vesicle formation [J].

Beck, Rainer ;

Sun, Zhe ;

Adolf, Frank ;

Rutz, Chistoph ;

Bassler, Jochen ;

Wild, Klemens ;

Sinning, Irmgard ;

Hurt, Ed ;

Bruegger, Britta ;

Bethune, Julien ;

Wieland, Felix .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (33) :11731-11736

[5]

ATP8B1 Deficiency Disrupts the Bile Canalicular Membrane Bilayer Structure in Hepatocytes, But FXR Expression and Activity Are Maintained [J].

Cai, Shi-Ying ;

Gautam, Samir ;

Nguyen, Trong ;

Soroka, Carol J. ;

Rahner, Christoph ;

Boyer, James L. .

GASTROENTEROLOGY, 2009, 136 (03) :1060-1069

[6]

The Arf activator Gea2p and the P-type ATPase Drs2p interact at the golgi in Saccharomyces cerevisiae [J].

Chantalat, S ;

Park, SK ;

Hua, ZL ;

Liu, K ;

Gobin, R ;

Peyroche, A ;

Rambourg, A ;

Graham, TR ;

Jackson, CL .

JOURNAL OF CELL SCIENCE, 2004, 117 (05) :711-722

[7]

Role for Drs2p, a P-type ATPase and potential aminophospholipid translocase, in yeast late Golgi function [J].

Chen, CY ;

Ingram, MF ;

Rosal, PH ;

Graham, TR .

JOURNAL OF CELL BIOLOGY, 1999, 147 (06) :1223-1236

[8]

Ypt31/32 GTPases and their novel F-box effector protein Rcy1 regulate protein recycling [J].

Chen, SH ;

Chen, S ;

Tokarev, AA ;

Liu, FL ;

Jedd, G ;

Segev, N .

MOLECULAR BIOLOGY OF THE CELL, 2005, 16 (01) :178-192

[9]

Roles for the Drs2p-Cdc50p complex in protein transport and phosphatidylserine asymmetry of the yeast plasma membrane [J].

Chen, Sophie ;

Wang, Jiyi ;

Muthusamy, Baby-Periyanayaki ;

Liu, Ke ;

Zare, Sara ;

Andersen, Raymond J. ;

Graham, Todd R. .

TRAFFIC, 2006, 7 (11) :1503-1517

[10]

Localization, Purification, and Functional Reconstitution of the P4-ATPase Atp8a2, a Phosphatidylserine Flippase in Photoreceptor Disc Membranes [J].

Coleman, Jonathan A. ;

Kwok, Michael C. M. ;

Molday, Robert S. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (47) :32670-32679

← 1 2 3 4 5 6 7 8 9 10 →