Bacterial toxins and the Rho GTP-binding protein: what microbes teach us about cell regulation

被引：23

作者：

Fiorentini, C

Gauthier, N

Donelli, G

Boquet, P

机构：

[1] Ist Super Sanita, Dept Ultrastruct, I-00161 Rome, Italy

[2] INSERM, U452, Fac Med, F-06107 Nice 2, France

来源：

CELL DEATH AND DIFFERENTIATION | 1998年 / 5卷 / 09期

关键词：

Rho; C3; CNF1; cell regulation;

D O I：

10.1038/sj.cdd.4400412

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the present review activities of two bacterial toxins, Clostridium botulinum exoenzyme C3 and Escherichia coli CNF1, both acting on the GTP-binding protein Rho are analyzed, Proteins belonging to the Rho family regulate the actin cytoskeleton and act as molecular switches in a number of signal transduction pathways. C3 and CNF1 have opposite effects on Rho thus representing useful tools for studies on cell division, cell differentiation and apoptosis.

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收藏

页码：720 / 728

页数：9

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