Type IICAAX prenyl endopeptidases belong to a novel superfamily of putative membrane-bound metalloproteases

被引：104

作者：

Pei, JM

Grishin, NV

机构：

[1] Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 05期

关键词：

D O I：

10.1016/S0968-0004(01)01813-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this article, a novel, large and diverse superfamily of putative membrane-bound proteins that includes the type II CAAX prenyl endopeptidases is described. The majority of the members of this superfamily are hypothetical proteins from bacteria acid plants. Analysis of the conserved motifs, combined with available experimental data, suggests that these proteins are putative metal-dependent proteases that are potentially involved in protein and/or peptide modification and secretion.

引用

页码：275 / 277

页数：3

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