DNA vaccines for biodefence

被引：21

作者：

Garmory, HS

Perkins, SD

Phillpotts, RJ

Titball, RW

机构：

[1] Def Sci & Technol Org, Dept Biomed Sci, Salisbury SP4 0JQ, Wilts, England

[2] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2005年 / 57卷 / 09期

关键词：

immunity; targeting; co-stimulatory molecules; delivery; carriers; regimens; viruses; bacteria;

D O I：

10.1016/j.addr.2005.01.013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The advantages associated with DNA vaccines include the speed with which they may be constructed and produced at large-scale, the ability to produce a broad spectrum of immune responses, and the ability for delivery using non-invasive means. In addition, DNA vaccines may be manipulated to express multiple antigens and may be tailored for the induction of appropriate immune responses. These advantages make DNA vaccination a promising approach for the development of vaccines for biodefence. In this review, the potential of DNA vaccines for biodefence is discussed. Crown Copyright (c) 2005 Published by Elsevier B.V. All rights reserved.

引用

页码：1343 / 1361

页数：19

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