Hepatitis C viral life cycle

被引：100

作者：

Suzuki, Tetsuro ^{[1
]}

Ishii, Koji ^{[1
]}

Aizaki, Hideki ^{[1
]}

Wakita, Takaji ^{[1
]}

机构：

[1] Natl Inst Infect Dis, Dept Virol 2, Shinjuku Ku, Tokyo 1628640, Japan

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2007年 / 59卷 / 12期

关键词：

hepatitis C virus; translation; polyprotein processing; RNA replication; viral assembly;

D O I：

10.1016/j.addr.2007.04.014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hepatitis C virus (HCV) has been recognized as a major cause of chronic liver diseases worldwide. Molecular studies of the virus became possible with the successful cloning of its genome in 1989. Although much work remains to be done regarding early and late stages of the HCV life cycle, significant progress has been made with respect to the molecular biology of HCV, especially the viral protein processing and the genome replication. This review summarizes our current understanding of genomic organization of HCV, features of the viral protein characteristics, and the viral life cycle. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：1200 / 1212

页数：13

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