Genetic control of resistance to trypanosomiasis

被引：23

作者：

Kemp, SJ

Darvasi, A

Soller, M

Teale, AJ

机构：

[1] INT LIVESTOCK RES INST,NAIROBI,KENYA

[2] HEBREW UNIV JERUSALEM,DEPT GENET,IL-91904 JERUSALEM,ISRAEL

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 1996年 / 54卷 / 1-4期

关键词：

genetic control; resistance; trypanosomiasis;

D O I：

10.1016/S0165-2427(96)05692-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To map the genetic sources of trypanotolerance in mice, a linkage analysis of survival following trypanosome challenge was performed by selective genotyping in a large F-2 population produced by crossing the resistant C57BL/6 and susceptible BALB/c inbred mouse lines. We report evidence of a chromosomal region of large effect, possibly comprising more than one resistance locus, on Chromosome 17; and of further loci on Chromosomes 1 and 5. Together, these genes can account for all of the difference between the mean parental phenotypes.

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收藏

页码：239 / 243

页数：5

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