Antitumor activity of HER-2 inhibitors

被引：74

作者：

Rabindran, SK ^{[1
]}

机构：

[1] Wyeth Res, Pearl River, NY 10965 USA

来源：

CANCER LETTERS | 2005年 / 227卷 / 01期

关键词：

HER-2; ErbB-2; neu; receptor tyrosine kinase; kinase inhibitors; breast cancer;

D O I：

10.1016/j.canlet.2004.11.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Activation of intracellular mitogenic signal transduction pathways driven by the ErbB family of receptor tyrosine kinases has been implicated in a variety of cancers. Amongst these, the tumorigenic roles of the Epidermal Growth Factor receptor (EGFR) and HER-2 have been most extensively studied. Therapeutic antibodies and small molecule kinase inhibitors targeting EGFR have recently received regulatory agency approval for the treatment of colon and lung cancer, respectively. In this review, I briefly describe these agents and their potential use in inhibiting the growth of tumors that overexpress HER-2. I also discuss other therapeutics currently available or being developed specifically to target HER-2 dependent tumors. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：9 / 23

页数：15

共 156 条

[1] Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth [J].