A mutation in Bruton's tyrosine kinase as a cause of selective anti-polysaccharide antibody deficiency

被引：44

作者：

Wood, PMD ^{[1
]}

Mayne, A

Joyce, H

Smith, CIE

Granoff, DM

Kumararatne, DS

机构：

[1] Univ Birmingham, MRC, Ctr Immune Regulat, Birmingham B15 2TT, W Midlands, England

[2] Birmingham Heartlands Hosp, Dept Immunol, Birmingham B9 5ST, W Midlands, England

[3] Karolinska Inst, Novum, Clin Res Ctr, Huddinge, Sweden

[4] Sandwell Gen Hosp, Dept Pediat, Sandwell, England

[5] Childrens Hosp, Oakland Res Inst, Oakland, CA 94609 USA

来源：

JOURNAL OF PEDIATRICS | 2001年 / 139卷 / 01期

关键词：

D O I：

10.1067/mpd.2001.115970

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Children and adults can have recurrent infection with invasive encapsulated bacterial pathogens such as Streptococcus pneumoniae as a result of a selective inability to respond to polysaccharide antigens. We have identified a mutation in the gene encoding Bruton's tyrosine kinase in a male patient with selective anti-polysaccharide antibody deficiency.

引用

页码：148 / 151

页数：4

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