Yos9, a control protein for misfolded glycosylated and non-glycosylated proteins in ERAD

被引：21

作者：

Benitez, Elena Martinez ^{[1
]}

Stolz, Alexandra ^{[1
]}

Wolf, Dieter H. ^{[1
]}

机构：

[1] Univ Stuttgart, Inst Biochem, D-70569 Stuttgart, Germany

来源：

FEBS LETTERS | 2011年 / 585卷 / 19期

关键词：

ER associated degradation; N-glycosylation; Misfolded protein; Lectin Yos9; CPY*0000; MRH domain; RETICULUM-ASSOCIATED DEGRADATION; ENDOPLASMIC-RETICULUM; IDENTIFIES YOS9P; UBIQUITIN-LIGASE; QUALITY-CONTROL; YEAST; COMPLEX; SIGNAL; GLYCOPROTEINS; NECESSITY;

D O I：

10.1016/j.febslet.2011.08.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The endoplasmic reticulum (ER) is responsible for folding and delivery of secretory proteins to their site of action. One major modification proteins undergo in this organelle is N-glycosylation. Proteins that cannot fold properly will be directed to a process known as endoplasmic reticulum associated degradation (ERAD). Processing of N-glycans generates a signal for ERAD. The lectin Yos9 recognizes the N-glycan signal of misfolded proteins and acts as a gatekeeper for the delivery of these substrates to the cytoplasm for degradation. Presence of Yos9 accelerates degradation of the glycosylated model ERAD substrate CPY*. Here we show that Yos9 has also a control function in degradation of the unglycosylated ERAD substrate CPY*0000. It decelerates its degradation rate. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：3015 / 3019

页数：5

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