Expression of the tumor suppressor miR-206 is associated with cellular proliferative inhibition and impairs invasion in ERα-positive endometrioid adenocarcinoma

被引：95

作者：

Chen, Xiaoyue ^{[1
]}

Yan, Qin ^{[1
]}

Li, Shuangdi ^{[2
]}

Zhou, Long ^{[1
]}

Yang, Huajing ^{[1
]}

Yang, Yixia ^{[2
]}

Liu, Xuelian ^{[2
]}

Wan, Xiaoping ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Int Peace Matern & Child Hlth Hosp, Shanghai 200030, Peoples R China

[2] Shanghai Jiao Tong Univ, Dept Obstet & Gynecol, Shanghai Peoples Hosp 1, Sch Med, Shanghai 200030, Peoples R China

来源：

CANCER LETTERS | 2012年 / 314卷 / 01期

关键词：

Endometrial endometrioid adenocarcinoma (EEC); MicroRNA-206 (miR-206); Estrogen receptor alpha (ER alpha); ESTROGEN-RECEPTOR-ALPHA; PROMOTING PROLIFERATION; ESR1; AMPLIFICATION; MESSENGER-RNA; CANCER; CARCINOMA; MICRORNA; GRADE; MMP-2;

D O I：

10.1016/j.canlet.2011.09.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

This study investigated the role of miR-206 in estrogen receptor-alpha (ER alpha)-positive endometrial endometrioid adenocarcinoma (EEC). We profiled miR-206 expression in 30 EEC clinical samples using qRT-PCR, and explored its relationship with ER alpha and clinical parameters. A luciferase reporter assay assessed the ER alpha targeting potential of miR-206. Functional analyses of miR-206 were performed in EEC cell lines. MiRNA-206 expression decreased in ER alpha-positive EECs, and its expression was negatively correlated with ER alpha. MiRNA-206 overexpression inhibited ER alpha-dependent proliferation, impaired invasiveness and induced cell cycle arrest of ER alpha-positive EEC cell lines. Therefore, aberrantly expressed miRNA-206 may be associated with the development of ER alpha-positive EEC. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：41 / 53

页数：13

共 44 条

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