Inhibition of lordosis behavior by intrahypothalamic infusion of a protein kinase G antagonist

被引：6

作者：

Jackson, A

Etgen, AM

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA

[2] Yeshiva Univ Albert Einstein Coll Med, Dept Psychiat, Bronx, NY 10461 USA

来源：

BRAIN RESEARCH | 2001年 / 919卷 / 01期

关键词：

lordosis; ventromedial hypothalamus; protein kinase G; estradiol; progesterone;

D O I：

10.1016/S0006-8993(01)03043-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous experiments demonstrated that intracerebroventricular infusion of the protein kinase G inhibitor KT5823 inhibits lordosis behavior in hormone-treated female rats. Present studies show that KT5823 attenuates lordosis in a dose-dependent manner when infused bilaterally into the ventromedial hypothalamus. Thus, activation of protein kinase G in the ventromedial hypothalamus is necessary for the expression of hormone-dependent lordosis behavior in female rats. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：175 / 178

页数：4

相关论文

共 27 条

[1] Evidence for a physiological role for nitric oxide in the regulation of the LH surge: Effect of central administration of antisense oligonucleotides to nitric oxide synthase [J].

Aguan, K ;

Mahesh, VB ;

Ping, L ;

Bhat, G ;

Brann, DW .

NEUROENDOCRINOLOGY, 1996, 64 (06) :449-455

[2]

Barfield R. J., 1982, HORMONES BEHAVIOUR H, P2

[3] INDUCTION OF FEMALE SEXUAL-BEHAVIOR BY GTP IN OVARIECTOMIZED ESTROGEN PRIMED RATS [J].

BEYER, C ;

FERNANDEZGUASTI, A ;

RODRIGUEZMANZO, G .

PHYSIOLOGY & BEHAVIOR, 1982, 28 (06) :1073-1076

[4] Evidence that brain nitric oxide synthase is the major nitric oxide synthase isoform in the hypothalamus of the adult female rat and that nitric oxide potently regulates hypothalamic cGMP levels [J].

Bhat, G ;

Mahesh, VB ;

Aguan, K ;

Brann, DW .

NEUROENDOCRINOLOGY, 1996, 64 (02) :93-102

[5]

Blaustein J. D., 1989, Advances in Comparative and Environmental Physiology, V3, P31

[6] EVIDENCE THAT NITRIC-OXIDE MAY MEDIATE THE OVARIAN STEROID-INDUCED LUTEINIZING-HORMONE SURGE - INVOLVEMENT OF EXCITATORY AMINO-ACIDS [J].

BONAVERA, JJ ;

SAHU, A ;

KALRA, PS ;

KALRA, SP .

ENDOCRINOLOGY, 1993, 133 (06) :2481-2487

[7] Nitric oxide synthase content of hypothalamic explants: Increased by norepinephrine and inactivated by NO and cGMP [J].

Canteros, G ;

Rettori, V ;

Genaro, A ;

Suburo, A ;

Gimeno, M ;

McCann, SM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (09) :4246-4250

[8] Cyclic GMP may potentiate lordosis behaviour by progesterone receptor activation [J].

Chu, HP ;

Morales, JC ;

Etgen, AM .

JOURNAL OF NEUROENDOCRINOLOGY, 1999, 11 (02) :107-113

[9] Ovarian hormone dependence of α1-adrenoceptor activation of the nitric oxide-cGMP pathway:: Relevance for hormonal facilitation of lordosis behavior [J].

Chu, HP ;

Etgen, AM .

JOURNAL OF NEUROSCIENCE, 1999, 19 (16) :7191-7197

[10] REPRODUCTIVE NEUROENDOCRINE REGULATION IN THE FEMALE RAT BY CENTRAL CATECHOLAMINE-NEUROPEPTIDE INTERACTIONS - A LOCAL-CONTROL HYPOTHESIS [J].

CROWLEY, WR .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1986, 474 :423-436