Design, synthesis, and evaluation of novel boronic-chalcone derivatives as antitumor agents

被引：303

作者：

Kumar, SK ^{[1
]}

Hager, E ^{[1
]}

Pettit, C ^{[1
]}

Gurulingappa, H ^{[1
]}

Davidson, NE ^{[1
]}

Khan, SR ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Div Expt Therapeut, Baltimore, MD 21231 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2003年 / 46卷 / 14期

关键词：

D O I：

10.1021/jm030213+

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of boronic-chalcone derivatives were synthesized and tested for antitumor activity against human breast cancer cell lines. The results show the boronic-chalcones are more toxic to breast cancer cells compared to normal breast cells than other known chalcones.

引用

页码：2813 / 2815

页数：3

共 34 条

[1] SUPPRESSION OF HUMAN COLORECTAL-CARCINOMA CELL-GROWTH BY WILD-TYPE-P53
BAKER, SJ
MARKOWITZ, S
FEARON, ER
WILLSON, JKV
VOGELSTEIN, B
[J]. SCIENCE, 1990, 249 (4971) : 912 - 915
[2] Synthesis and biological activity of 4-alkoxy chalcones: Potential hydrophobic modulators of P-glycoprotein-mediated multidrug resistance
Bois, F
Boumendjel, A
Mariotte, AM
Conseil, G
Di Petro, A
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 1999, 7 (12) : 2691 - 2695
[3] A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2
Boyd, MT
Vlatkovic, N
Haines, DS
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (41) : 31883 - 31890
[4] Calliste CA, 2001, ANTICANCER RES, V21, P3949
[5] CHABNER BA, 1990, CANC CHEMOTHERAPY PR, P9
[6] Organolithium mediated synthesis of prenylchalcones as potential inhibitors of chemoresistance
Daskiewicz, JB
Comte, G
Barron, D
Di Pietro, A
Thomasson, F
[J]. TETRAHEDRON LETTERS, 1999, 40 (39) : 7095 - 7098
[7] DEVINCENZO R, 1995, ANTI-CANCER DRUG DES, V10, P481
[8] DiCesare N, 2002, TETRAHEDRON LETT, V43, P2615, DOI 10.1016/s0040-4039(02)00312-x
[9] P53 FUNCTIONS AS A CELL-CYCLE CONTROL PROTEIN IN OSTEOSARCOMAS
DILLER, L
KASSEL, J
NELSON, CE
GRYKA, MA
LITWAK, G
GEBHARDT, M
BRESSAC, B
OZTURK, M
BAKER, SJ
VOGELSTEIN, B
FRIEND, SH
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (11) : 5772 - 5781
[10] EZIO B, 1998, PREPARATION CHALCONE

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