Design, synthesis, and evaluation of novel boronic-chalcone derivatives as antitumor agents

被引:303
作者
Kumar, SK [1 ]
Hager, E [1 ]
Pettit, C [1 ]
Gurulingappa, H [1 ]
Davidson, NE [1 ]
Khan, SR [1 ]
机构
[1] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Div Expt Therapeut, Baltimore, MD 21231 USA
关键词
D O I
10.1021/jm030213+
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A series of boronic-chalcone derivatives were synthesized and tested for antitumor activity against human breast cancer cell lines. The results show the boronic-chalcones are more toxic to breast cancer cells compared to normal breast cells than other known chalcones.
引用
收藏
页码:2813 / 2815
页数:3
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