Dynamics of hepatitis C viremia following interferon-α administration

被引：54

作者：

Yasui, K ^{[1
]}

Okanoue, T ^{[1
]}

Murakami, Y ^{[1
]}

Itoh, Y ^{[1
]}

Minami, M ^{[1
]}

Sakamoto, S ^{[1
]}

Sakamoto, M ^{[1
]}

Nishioji, K ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Dept Internal Med 3, Kamigyo Ku, Kyoto 602, Japan

来源：

JOURNAL OF INFECTIOUS DISEASES | 1998年 / 177卷 / 06期

关键词：

D O I：

10.1086/515309

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Knowledge of the dynamics of hepatitis C virus (HCV) in vivo is important for elucidation of its pathogenesis and the establishment of therapeutic guidelines. The aim of this study was to obtain kinetic information about virus load following interferon-alpha (IFN-alpha) administration. Serial serum HCV core protein and HCV RNA levels were measured. IFN-alpha exponentially reduced serum HCV levels. The mean (+/-SD) viral half-life was 7.0 +/- 2.6 h in HCV core protein assay and 7.2 +/- 3.1 h in HCV RNA assay on the first day of therapy, This initial rapid decrease was followed by a slower decrease in serum HCV levels thereafter, Thus, the biphasic reduction in virus load during IFN-alpha therapy was demonstrated.

引用

页码：1475 / 1479

页数：5

共 18 条

[1] TREATMENT OF CHRONIC HEPATITIS-C WITH RECOMBINANT INTERFERON-ALFA - A MULTICENTER RANDOMIZED, CONTROLLED TRIAL [J].

DAVIS, GL ;

BALART, LA ;

SCHIFF, ER ;

LINDSAY, K ;

BODENHEIMER, HC ;

PERRILLO, RP ;

CAREY, W ;

JACOBSON, IM ;

PAYNE, J ;

DIENSTAG, JL ;

VANTHIEL, DH ;

TAMBURRO, C ;

LEFKOWITCH, J ;

ALBRECHT, J ;

MESCHIEVITZ, C ;

ORTEGO, TJ ;

GIBAS, A .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (22) :1501-1506

[2]

DESMET VJ, 1994, HEPATOLOGY, V19, P1513, DOI 10.1002/hep.1840190629

[3] RECOMBINANT INTERFERON-ALFA THERAPY FOR CHRONIC HEPATITIS-C - A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].

DIBISCEGLIE, AM ;

MARTIN, P ;

KASSIANIDES, C ;

LISKERMELMAN, M ;

MURRAY, L ;

WAGGONER, J ;

GOODMAN, Z ;

BANKS, SM ;

HOOFNAGLE, JH .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (22) :1506-1510

[4] Viral dynamics of hepatitis C early after orthotopic liver transplantation: Evidence for rapid turnover of serum virions [J].

Fukumoto, T ;

Berg, T ;

Ku, Y ;

Bechstein, WO ;

Knoop, M ;

Lemmens, HP ;

Lobeck, H ;

Hopf, U ;

Neuhaus, P .

HEPATOLOGY, 1996, 24 (06) :1351-1354

[5] RAPID TURNOVER OF PLASMA VIRIONS AND CD4 LYMPHOCYTES IN HIV-1 INFECTION [J].

HO, DD ;

NEUMANN, AU ;

PERELSON, AS ;

CHEN, W ;

LEONARD, JM ;

MARKOWITZ, M .

NATURE, 1995, 373 (6510) :123-126

[6] Detection of hepatitis C virus specific core protein in serum of patients by a sensitive fluorescence enzyme immunoassay (FEIA) [J].

Kashiwakuma, T ;

Hasegawa, A ;

Kajita, T ;

Takata, A ;

Mori, H ;

Ohta, Y ;

Tanaka, E ;

Kiyosawa, K ;

Tanaka, T ;

Tanaka, S ;

Hattori, N ;

Kohara, M .

JOURNAL OF IMMUNOLOGICAL METHODS, 1996, 190 (01) :79-89

[7]

KOHARA M, 1995, J INFECT DIS, V172, P934, DOI 10.1093/infdis/172.4.934

[8]

Lam NP, 1997, HEPATOLOGY, V26, P226

[9] SIGNIFICANCE OF SERUM HEPATITIS-C VIRUS-RNA LEVELS IN CHRONIC HEPATITIS-C [J].

LAU, JYN ;

DAVIS, GL ;

KNIFFEN, J ;

QIAN, KP ;

URDEA, MS ;

CHAN, CS ;

MIZOKAMI, M ;

NEUWALD, PD ;

WILBER, JC .

LANCET, 1993, 341 (8859) :1501-1504

[10]

SIMMONDS P, 1994, HEPATOLOGY, V19, P1321, DOI 10.1016/0270-9139(94)90887-7

← 1 2 →