Shiga toxin-mediated retrograde delivery of a topoisomerase I inhibitor prodrug

被引：65

作者：

El Alaoui, Abdessamad

Schmidt, Frederic

Amessou, Mohamed

Sarr, Marianne

Decaudin, Didier

Florent, Jean-Claude

Johannes, Ludger

机构：

[1] Inst Curie, Ctr Rech, CNRS, UMR 176, F-75248 Paris 05, France

[2] Inst Curie, Ctr Rech, CNRS, UMR 144, F-75248 Paris, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 34期

关键词：

antitumor agents; drug delivery; prodrugs retrograde; transport; Shiga toxin;

D O I：

10.1002/anie.200701270

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) A retrograde strategy: An innovative cancer-cell delivery concept exploits the naturally evolved characteristics of the Shiga toxin B-subunit (STxB) for the intracellular activation of a newly synthesized prodrug at the level of the biosynthetic/secretory pathway (see picture). Retrograde prodrug targeting allows its slow release, which should sustain the presence of the active principle in dividing tumor cells. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：6469 / 6472

页数：4

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