Induction of KAI-1 expression in metastatic cancer cells by phorbol esters

被引：20

作者：

Akita, H

Iizuka, A

Hashimoto, Y

Kohri, K

Ikeda, K

Nakanishi, M

机构：

[1] Natl Inst Longev Sci, Dept Geriatr Res, Aichi 4748522, Japan

[2] Nagoya City Univ, Sch Med, Dept Urol, Mizuho Ku, Nagoya, Aichi 4678601, Japan

[3] Nagoya City Univ, Sch Med, Dept Biochem, Mizuho Ku, Nagoya, Aichi 4678601, Japan

来源：

CANCER LETTERS | 2000年 / 153卷 / 1-2期

关键词：

KAI-1; expression; metastatic cancer cells; phorbol esters;

D O I：

10.1016/S0304-3835(00)00352-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

KAI-1 is a tumor suppressor gene whose down-regulation has been shown to be associated with the development of metastases of cancer cells, Here, we demonstrated that KAI-1 expression was induced by activating protein kinase C even in metastatic prostate cancer cell lines in which its expression was significantly down-regulated, KAI-1 expression was enhanced in a dose-dependent manner by PMA, and its induction is at least in part due to transcriptional activation, Pretreatment with calphostin C abrogated its induction by PMA. Our findings may provide useful information for developing a novel drug capable of inducing KAI-1 expression and thereby inhibiting metastasis, (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：79 / 83

页数：5

共 21 条

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