Coexpression of the beta 2 subunit does not induce voltage-dependent facilitation of the class C L-type Ca channel

被引：43

作者：

Cens, T ^{[1
]}

Mangoni, ME ^{[1
]}

Richard, S ^{[1
]}

Nargeot, J ^{[1
]}

Charnet, P ^{[1
]}

机构：

[1] CNRS,CRBM,UPR 9008,INSERM,U249,F-34033 MONTPELLIER,FRANCE

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 1996年 / 431卷 / 05期

关键词：

L-type Ca channel; current facilitation; beta subunit; rat heart;

D O I：

10.1007/s004240050064

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Voltage-dependent facilitation of L-type Ca2+ channels is an important regulatory mechanism by which excitable cells modulate Ca2+ entry during a train of action potentials. Expression of the alpha(1) and beta subunits of the alpha(1C) Ca2+ channel is necessary and sufficient to reproduce this kind of facilitation in Xenopus oocytes. Here we show that, by expressing the alpha(1C) together with different beta subunits in oocytes, the beta(1), beta(3) and beta(4), but not the beta(2) subunits are permissive for Ca2+ channel facilitation. The poor facilitation observed in rat ventricular cells, together with the presence of the beta(2) subunit mRNA, suggest that beta(2) may be the beta subunit associated with functional cardiac L-type Ca2+ channels.

引用

页码：771 / 774

页数：4

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