The acyclic nucleoside phosphonate analogues, adefovir, tenofovir and PMEDAP, efficiently eliminate banana streak virus from banana (Musa spp.)

被引：17

作者：

Helliot, B

Panis, B

Frison, E

De Clercq, E

Swennen, R

Lepoivre, P

Neyts, J ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

[2] Gembloux Agr Univ, Plant Pathol Unit, B-5030 Gembloux, Belgium

[3] Katholieke Univ Leuven, Lab Trop Crop Improvement, B-3001 Heverlee, Belgium

[4] IPGRI, INIBAP, F-34397 Montpellier, France

来源：

ANTIVIRAL RESEARCH | 2003年 / 59卷 / 02期

关键词：

adefovir; tenofovir; badnavirus; pararetrovirus; banana streak virus; chemotherapy; hepadnavirus; virus eradication;

D O I：

10.1016/S0166-3542(03)00067-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We report that the anti-retroviral and anti-hepadnavirus molecules, adefovir, tenofovir and 9-(2-phosphonomethoxyethyl)-2,6-diaminopurine (PMEDAP), efficiently eradicate the episomal form of Banana streak virus (BSV) from banana plants. Up to 90% of plants regenerated from BSV-infected highly proliferating meristems were virus free following a 6-month treatment period with 10 mug/ml (a non-phytotoxic concentration) of either compounds. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：121 / 126

页数：6

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