Phenotypic patterns of distortion product otoacoustic emission in inbred and F-1 hybrid hearing mouse strains

被引：2

作者：

Huang, JM ^{[1
]}

Money, MK ^{[1
]}

Berlin, CI ^{[1
]}

Keats, BJB ^{[1
]}

机构：

[1] LOUISIANA STATE UNIV, MED CTR, DEPT BIOMETRY & GENET, NEW ORLEANS, LA 70112 USA

来源：

HEARING RESEARCH | 1996年 / 98卷 / 1-2期

关键词：

CBA/J; curly-tail mouse; deafness mouse; genotype; heterosis; hybrid; inbred; MOLF/Rk; otoacoustic emission; phenotype;

D O I：

10.1016/0378-5955(96)00041-X

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

Distortion product otoacoustic emissions (DPOE) were obtained from five different hearing mouse groups: CBA/J, MOLF/Rk, ct (homozygous normal mice of the curly-tail stock), and the F-1 hybrid offspring of the matings CBA/J x dn/dn and MOLF/Rk x dn/dn (dn/dn mice are the curly-tail stock with recessive deafness). The DPOE patterns of the CBA/J and ct strains were similar to each other and different from that of the MOLF/Rk. The two sets of F-1 hybrid mice, (CBA/J x dn/dn)F-1 and (MOLF/Rk x dn/dn)F-1, were found to have significantly larger DPOE amplitudes than their hearing parent strains, MOLF/Rk and CBA/J, respectively. In addition, the DPOE amplitudes were greater for the offspring of the MOLF/Rk x dn/dn cross than for those of the CBA/J x dn/dn cross, even though they were lower for MOLF/Rk than for CBA/J. The distinct features of DPOE patterns among these five groups suggest that DPOE testing can be used for auditory phenotyping.

引用

页码：18 / 21

页数：4

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