Resting and activated endothelial cells are increased in the peripheral blood of cancer patients

被引：347

作者：

Mancuso, P

Burlini, A

Pruneri, G

Goldhirsch, A

Martinelli, G

Bertolini, F

机构：

[1] European Inst Oncol, Div Hematol Oncol, I-20141 Milan, Italy

[2] European Inst Oncol, Div Pathol Lab Med, I-20141 Milan, Italy

[3] European Inst Oncol, Div Med Oncol, I-20141 Milan, Italy

来源：

BLOOD | 2001年 / 97卷 / 11期

关键词：

D O I：

10.1182/blood.V97.11.3658

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Circulating endothelial cells (CECs) were enumerated in 20 healthy controls and 76 newly diagnosed cancer patients by means of a-color flow cytometry. In breast cancer (n = 46) and lymphoma (n = 30) patients, both resting and activated CECs were increased by 5-fold (P < .0008 vs control). CECs significantly correlated with plasma levels of vascular cell adhesion molecule-1 and vascular endothelial growth factor. Resting and activated CECs were similar to healthy controls in 7 lymphoma patients achieving complete remission after chemotherapy, and activated CECs were found to decrease in 13 breast cancer patients evaluated before and 24 hours after quadrantectomy.

引用

页码：3658 / 3661

页数：4

共 21 条

[1] VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells
Asahara, T
Takahashi, T
Masuda, H
Kalka, C
Chen, DH
Iwaguro, H
Inai, Y
Silver, M
Isner, JM
[J]. EMBO JOURNAL, 1999, 18 (14) : 3964 - 3972
[2] Angiogenic growth factors and endostatin in non-Hodgkin's lymphoma
Bertolini, F
Paolucci, M
Peccatori, F
Cinieri, S
Agazzi, A
Ferrucci, PF
Cocorocchio, E
Goldhirsch, A
Martinelli, G
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 1999, 106 (02) : 504 - 509
[3] Serum soluble vascular cell adhesion molecule-1: Role as a surrogate marker of angiogenesis
Byrne, GJ
Ghellal, A
Iddon, J
Blann, AD
Venizelos, V
Kumar, S
Howell, A
Bundred, NJ
[J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (16) : 1329 - 1336
[4] Mosaic blood vessels in tumors: Frequency of cancer cells in contact with flowing blood
Chang, YS
di Tomaso, E
McDonald, DM
Jones, R
Jain, RK
Munn, LL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (26) : 14608 - 14613
[5] DIAGNOSIS OF MEDITERRANEAN SPOTTED-FEVER BY INDIRECT IMMUNOFLUORESCENCE OF RICKETTSIA-CONORII IN CIRCULATING ENDOTHELIAL-CELLS ISOLATED WITH MONOCLONAL-ANTIBODY COATED IMMUNOMAGNETIC BEADS
DRANCOURT, M
GEORGE, F
BROUQUI, P
SAMPOL, J
RAOULT, D
[J]. JOURNAL OF INFECTIOUS DISEASES, 1992, 166 (03) : 660 - 663
[6] Incipient angiogenesis
Folkman, J
[J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (02): : 94 - 95
[7] Flow cytometry counting of CD34+ cells in whole blood
Fornas, O
Garcia, J
Petriz, J
[J]. NATURE MEDICINE, 2000, 6 (07) : 833 - +
[8] CYTOFLUOROMETRIC DETECTION OF HUMAN ENDOTHELIAL-CELLS IN WHOLE-BLOOD USING S-ENDO-1 MONOCLONAL-ANTIBODY
GEORGE, F
PONCELET, P
LAURENT, JC
MASSOT, O
ARNOUX, D
LEQUEUX, N
AMBROSI, P
CHICHEPORTICHE, C
SAMPOL, J
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1991, 139 (01) : 65 - 75
[9] CIRCULATING CYTOMEGALOVIRUS (CMV)-INFECTED ENDOTHELIAL-CELLS IN PATIENTS WITH AN ACTIVE CMV INFECTION
GREFTE, A
VANDERGIESSEN, M
VANSON, W
THE, TH
[J]. JOURNAL OF INFECTIOUS DISEASES, 1993, 167 (02) : 270 - 277
[10] The hallmarks of cancer
Hanahan, D
Weinberg, RA
[J]. CELL, 2000, 100 (01) : 57 - 70

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