Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia

被引：31

作者：

Li, XC ^{[1
]}

Jacob, MR

ElSohly, HN

Nagle, DG

Smillie, TJ

Walker, LA

Clark, AM

机构：

[1] Univ Mississippi, Natl Ctr Nat Prod Res, Inst Pharmaceut Sci, University, MS 38677 USA

[2] Univ Mississippi, Dept Pharmacognosy, University, MS 38677 USA

[3] Univ Mississippi, Sch Pharm, Dept Pharmacol, University, MS 38677 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 08期

关键词：

D O I：

10.1021/np030196r

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Antifungal bioassay-guided isolation of the ethanol extract of the roots of Pentagonia gigantifolia yielded 6-octadecynoic acid (1) and the new 6-nonadecynoic acid (2). Compounds 1 and 2 inhibited the growth of fluconazole-susceptible and -resistant Candida albicans strains. Their antifungal potencies were comparable to those of amphotericin B and fluconazole. Of particular significance is the low cytotoxicity and specific activity of 1 and 2 against C. albicans.

引用

页码：1132 / 1135

页数：4

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