The teratology of autism

被引:270
作者
Arndt, TL [1 ]
Stodgell, CJ [1 ]
Rodier, PM [1 ]
机构
[1] Univ Rochester, Med Ctr, Dept Obstet & Gynecol, Rochester, NY 14642 USA
关键词
autism; autism spectrum disorders (ASDs); valproic acid; eyeblink conditioning; congenital malformations;
D O I
10.1016/j.ijdevneu.2004.11.001
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Autism spectrum disorders affect behaviors that emerge at ages when typically developing children become increasingly social and communicative, but many lines of evidence suggest that the underlying alterations in the brain occur long before the period when symptoms become obvious. Studies of the behavior of children in the first year of life demonstrate that symptoms are often detectable in the first 6 months. The environmental factors known to increase the risk of autism have critical periods of action during embryogenesis. Minor malformations that occur frequently in people with autism are known to arise in the same stages of development. Anomalies reported from histological studies of the brain are consistent with an early alteration of development. Congenital syndromes with high rates of autism include somatic that originate early in the first trimester. In addition, it is possible to duplicate a number of anatomic and behavioral features characteristic of human cases by exposing rat embryos to a teratogenic dose of valproic acid at the time of neural tube closure. (C) 2004 ISDN. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:189 / 199
页数:11
相关论文
共 122 条
[1]  
Anderson GM, 1990, ANN N Y ACAD SCI, V600, p[331, 341]
[2]   VERIFICATION OF THE FETAL VALPROATE SYNDROME PHENOTYPE [J].
ARDINGER, HH ;
ATKIN, JF ;
BLACKSTON, RD ;
ELSAS, LJ ;
CLARREN, SK ;
LIVINGSTONE, S ;
FLANNERY, DB ;
PELLOCK, JM ;
HARROD, MJ ;
LAMMER, EJ ;
MAJEWSKI, F ;
SCHINZEL, A ;
TORIELLO, HV ;
HANSON, JW .
AMERICAN JOURNAL OF MEDICAL GENETICS, 1988, 29 (01) :171-185
[3]  
ARNDT TL, 2003, TER M PHIL PA
[4]  
Aronson M, 1997, DEV MED CHILD NEUROL, V39, P583
[5]   A clinicopathological study of autism [J].
Bailey, A ;
Luthert, P ;
Dean, A ;
Harding, B ;
Janota, I ;
Montgomery, M ;
Rutter, M ;
Lantos, P .
BRAIN, 1998, 121 :889-905
[6]   Autism and Mobius sequence - An exploratory study of children in northeastern Brazil [J].
Bandim, JM ;
Ventura, LO ;
Miller, MT ;
Almeida, HC ;
Costa, AES .
ARQUIVOS DE NEURO-PSIQUIATRIA, 2003, 61 (2A) :181-185
[7]   HISTOANATOMIC OBSERVATIONS OF THE BRAIN IN EARLY INFANTILE-AUTISM [J].
BAUMAN, M ;
KEMPER, TL .
NEUROLOGY, 1985, 35 (06) :866-874
[8]  
Bauman M.L., 1994, NEUROBIOLOGY AUTISM, P119
[9]  
BAUMAN ML, 2000, CEREBELLUM COGNITION
[10]   Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly [J].
Belloni, E ;
Muenke, M ;
Roessler, E ;
Traverso, G ;
SiegelBartelt, J ;
Frumkin, A ;
Mitchell, HF ;
DonisKeller, H ;
Helms, C ;
Hing, AV ;
Heng, HHQ ;
Koop, B ;
Martindale, D ;
Rommens, JM ;
Tsui, LC ;
Scherer, SW .
NATURE GENETICS, 1996, 14 (03) :353-356