Susceptibility to Invasive Bacterial Infections in Children With Sickle Cell Disease

被引：56

作者：

Battersby, Anna J.

Knox-Macaulay, Huxley H. M. ^{[2
,3
]}

Carrol, Enitan D. ^{[1
]}

机构：

[1] Univ Liverpool, Div Child Hlth, Inst Child Hlth, Alder Hey Childrens NHS Fdn Trust, Liverpool L12 2AP, Merseyside, England

[2] Sultan Qaboos Univ, Univ Hosp, Dept Hematol, Coll Med, Muscat, Oman

[3] Sultan Qaboos Univ Hosp, Muscat, Oman

来源：

PEDIATRIC BLOOD & CANCER | 2010年 / 55卷 / 03期

关键词：

bacteremia; bacterial; immune; infection; sickle cell; PNEUMOCOCCAL CONJUGATE VACCINE; PLATELET-ACTIVATING-FACTOR; ALPHA-THALASSEMIA TRAIT; STREPTOCOCCUS-PNEUMONIAE; NASOPHARYNGEAL CARRIAGE; POLYSACCHARIDE VACCINE; PENICILLIN PROPHYLAXIS; COMPLEMENT ACTIVATION; 1ST DECADE; ANEMIA;

D O I：

10.1002/pbc.22461

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Individuals with sickle cell disease (SCD) demonstrate an increased susceptibility to invasive bacterial infections (IBI). The most common organisms causing IBI are Streptococcus pneumoniae, nontyphi Salmonella species and Haemophilus influenzae type b (Hib). IBI are the most common causes of death in children below 5 years of age with SCD. Increased susceptibility to IBI is because of several factors including dysfunctional antibody production and opsonophagocytosis as well as defective splenic clearance. Early diagnosis of Hib and pneumococcal infections combined with antibiotic prophylaxis and immunization programs, could lead to significant improvements in mortality, especially in Africa. Pediatr Blood Cancer 2010;55:401-406 (C) 2010 Wiley-Liss, Inc.

引用

页码：401 / 406

页数：6

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