Nuclear mRNA export: insights from virology

被引：234

作者：

Cullen, BR ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Howard Hughes Med Inst, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2003年 / 28卷 / 08期

关键词：

D O I：

10.1016/S0968-0004(03)00142-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To maximize the production of progeny virions, several viruses have evolved mechanisms that promote the selective nuclear export of viral mRNA transcripts while, in some cases, inhibiting the export of cellular mRNAs. To achieve this goal, viruses have evolved regulatory proteins and cis-acting RNA elements that selectively interact with key cellular nuclear export factors. Efforts to identify the cellular targets of these viral proteins and RNA elements have led to the identification of Crm1 and Tap as essential human nuclear RNA-export factors and continue to provide insights into how mRNAs are selected for export.

引用

页码：419 / 424

页数：6

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