Community-acquired pneumonia in children

被引:52
作者
Sinaniotis, CA [1 ]
Sinaniotis, AC
机构
[1] Univ Athens, Sch Med, A&P Kyriakou Childrens Hosp, Dept Pediat 2, Athens 11527, Greece
[2] Laikon Gen Hosp, Dept Allergy & Clin Immunol, Athens, Greece
关键词
antibiotic resistance; community-acquired pneumonia; empyema; pneumococcal conjugate vaccine; pleural effusion; respiratory syncytial virus;
D O I
10.1097/01.mcp.0000159831.82529.85
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Purpose of review This review highlights recent developments in the diagnosis, etiology, therapy, and prevention of community-acquired pneumonia in children. Recent findings Sensitive new diagnostic methods have increased the detection rate of the causative agent up to 94% Streptococcus pneumoniae is the most prevalent bacterial pathogen in all ages. Polymerase chain reaction is a rapid and sensitive method for the detection of Chlamydia pneumoniae and Mycoplasma pneumoniae, which have gained greater importance in recent years. During the period covered by this review, two new agents causing pneumonia were extensively studied. Human metapneumonovirus detected in young children is a leading cause of respiratory disease during the first years of life. A novel coronavirus was identified as the causative agent of severe repiratory syndrome, a new respiratory illness that affects adults and children. One multicenter trial concluded that nonsevere pneumonia can be treated with a short course of oral amoxicillin or parenteral penicillin, but more data are needed to demonstrate the safety and efficacy of such regimens. Summary The continued evolution of bacterial resistance highlights the need for appropriate use of antibacterials. Improved diagnostic technique will aid the treatment of children with community-acquired pneumonia. Aggressive vaccination with the pneumococcal conjugate vaccine and other available vaccines as well as the development of new vaccines will aid the development of new vaccines will aid the prevention of respiratory disease in children.
引用
收藏
页码:218 / 225
页数:8
相关论文
共 60 条
[1]   Oral amoxicillin versus injectable penicillin for severe pneumonia in children aged 3 to 59 months: a randomised multicentre equivalency study [J].
Addo-Yobo, E ;
Chisaka, N ;
Hassan, M ;
Hibberd, P ;
Lozano, JM ;
Jeena, P ;
MacLeod, WB ;
Maulen, I ;
Patel, A ;
Qazi, S ;
Thea, DM ;
Nguyen, NTV .
LANCET, 2004, 364 (9440) :1141-1148
[2]  
Awasthi S, 2004, BMJ-BRIT MED J, V328, P791
[3]  
*BTS, 2002, THORAX, V57, pS1
[4]   Incidence and etiologies of complicated parapneumonic effusions in children, 1996 to 2001 [J].
Buckingham, SC ;
King, MD ;
Miller, ML .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2003, 22 (06) :499-504
[5]   Bacteremia-associated pneumococcal pneumonia and the benefit of initial parenteral antimicrobial therapy [J].
Chumpa, A ;
Bachur, RG ;
Harper, MB .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1999, 18 (12) :1081-1085
[6]  
*CINC CHILDR HOSP, 2000, EV BAS CLIN PRACT GU, P1
[7]   Effectiveness of Haemophilus influenzae b conjugate vaccine on childhood pneumonia:: a case-control study in Brazil [J].
de Andrade, ALSS ;
de Andrade, JG ;
Martelli, CMT ;
Silva, SAE ;
de Oliveira, RM ;
Costa, MSN ;
Laval, CB ;
Ribeiro, LHV ;
Fabio, JLD .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2004, 33 (01) :173-181
[8]   Human metapneumovirus infection in the united states: Clinical manifestations associated with a newly emerging respiratory infection in children [J].
Esper, F ;
Boucher, D ;
Weibel, C ;
Martinello, RA ;
Kahn, JS .
PEDIATRICS, 2003, 111 (06) :1407-1410
[9]  
FINGUERASALOY J, 2004, PEDIATR INFECT DIS J, V23, P815
[10]  
Hazir T, 2002, LANCET, V360, P835