Metabolic syndrome in youths

被引:34
作者
Amemiya, Shin
Dobashi, Kazushige
Urakami, Tatsuhiko
Sugihara, Shigetaka
Ohzeki, Takehiko
Tajima, Naoko
机构
[1] Jikei Univ, Sch Med, Dept Med, Div Endocrinol Diabet & Metab,Minato Ku, Tokyo 1058461, Japan
[2] Saitama Med Univ, Dept Pediat, Saitama, Japan
[3] Univ Occupat & Environm Hlth, Dept Pediat, Kitakyushu, Fukuoka 807, Japan
[4] Nihon Univ, Sch Med, Dept Pediat, Tokyo, Japan
[5] Tokyo Womens Med Univ Med Ctr E, Dept Pediat, Tokyo, Japan
[6] Hamamatsu Univ Sch Med, Dept Pediat, Hamamatsu, Shizuoka 43131, Japan
[7] Jikei Univ, Sch Med, Dept Internal Med, Div Diabet Metab & Endocrinol, Tokyo, Japan
关键词
adiponectin; children; metabolic syndrome; obesity; prevalence;
D O I
10.1111/j.1399-5448.2007.00332.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The metabolic syndrome (MetS), characterized by a clustering of cardiovascular disease and type 2 diabetes (T2DM) risk factors, has become prevalent in children and adolescents in recent years. However, the reported prevalence data on the MetS in youths has varied markedly, in large part, because of the disagreement among the variously proposed definitions of the MetS. Obesity is defined by using body mass index, waist circumference, or percent overweight, pointing to the need for standardized use of anthropometric variables to define obesity with a well-defined reference year for each ethnic population. In addition, slightly different cutoff values are used for triglycerides, high-density lipoprotein cholesterol, blood pressure, and fasting plasma glucose. Therefore, International Diabetes Federation recently proposed unified, easy-to-use criteria for diagnosing the MetS in youths. To provide insight into the mechanisms underlying the MetS in youths, the degree of insulin sensitivity/resistance and its correlation with the serum lipid and blood pressure levels have been evaluated. In addition, the serum levels of adipocytokines, such as adiponectin, leptin, tumor necrosis factor-alpha, resistin, interleukin-6, plasminogen activator inhibitor-1, and their correlation with childhood obesity have been extensively investigated. Recommendations for future research include exploring ways to assess visceral adiposity, to identify better biochemical markers for prediction of T2DM and disease progression, and to effectively intervene to prevent the MetS in youths.
引用
收藏
页码:48 / 54
页数:7
相关论文
共 63 条
[1]   The metabolic syndrome - a new worldwide definition [J].
Alberti, KGMM ;
Zimmet, P ;
Shaw, J .
LANCET, 2005, 366 (9491) :1059-1062
[2]  
Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO
[3]  
2-S
[4]   High molecular weight, rather than total, adiponectin levels better reflect metabolic abnormalities associated with childhood obesity [J].
Araki, Shunsuke ;
Dobashi, Kazushige ;
Kubo, Kazuyasu ;
Asayama, Kohtaro ;
Shirahata, Akira .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (12) :5113-5116
[5]   Decrease in serum adiponectin level due to obesity and visceral fat accumulation in children [J].
Asayama, K ;
Hayashibe, H ;
Dobashi, K ;
Uchida, N ;
Nakane, T ;
Kodera, K ;
Shirahata, A ;
Taniyama, M .
OBESITY RESEARCH, 2003, 11 (09) :1072-1079
[6]   Criteria for medical intervention in obese children: A new definition of 'Obesity disease' in Japanese children [J].
Asayama, K ;
Ozeki, T ;
Sugihara, S ;
Ito, K ;
Okada, T ;
Tamai, H ;
Takaya, R ;
Hanaki, K ;
Murata, M .
PEDIATRICS INTERNATIONAL, 2003, 45 (05) :642-646
[7]   Are obesity-related metabolic risk factors modulated by the degree of insulin resistance in adolescents [J].
Bacha, Fida ;
Saad, Rola ;
Gungor, Neslihan ;
Arslanian, Silva A. .
DIABETES CARE, 2006, 29 (07) :1599-1604
[8]  
Balkau B, 1999, DIABETIC MED, V16, P442
[9]   Hemostatic and inflammatory markers in obese youths: Effects of exercise and adiposity [J].
Barbeau, P ;
Litaker, MS ;
Woods, KF ;
Lemmon, CR ;
Humphries, MC ;
Owens, C ;
Gutin, B .
JOURNAL OF PEDIATRICS, 2002, 141 (03) :415-420
[10]   Effect of a short-term diet and exercise intervention on metabolic syndrome in overweight children [J].
Chen, Andrew K. ;
Roberts, Christian K. ;
Barnard, R. James .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2006, 55 (07) :871-878