Obesity in Adolescence is Associated with Left Ventricular Hypertrophy and Hypertension

被引:24
作者
Movahed, Mohammad-Reza [1 ,2 ]
Bates, Sharon [3 ]
Strootman, Deborah [2 ]
Sattur, Sudhakar [2 ]
机构
[1] So Arizona VA Hlth Care Syst, Tucson, AZ 85724 USA
[2] Univ Arizona, Coll Med, Sarver Heart Ctr, Tucson, AZ 85721 USA
[3] Anthony Bates Fdn, Phoenix, AZ USA
来源
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES | 2011年 / 28卷 / 02期
关键词
LVH; hypertension; left ventricular hypertrophy; screening; overweight; obese; adolescents; echocardiography; screening echocardiography; WEIGHT-REDUCTION; BLOOD-PRESSURE; SYSTOLIC FUNCTION; TISSUE DOPPLER; CHILDREN; DYSFUNCTION; THICKNESS; DISEASE; GENDER; INDEX;
D O I
10.1111/j.1540-8175.2010.01289.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Obesity is a risk factor for hypertension (HTN) and left ventricular hypertrophy (LVH). However, the association between obesity, HTN or LVH in adolescents has not been studied in a large population. Method: Utilizing a database of screening echocardiograms, we assessed for the presence of LVH and HTN (defined as systolic blood pressure (SBP) > 140 mmHg or diastolic blood pressure (DBP) > 90 mmHg) in obese adolescents (BMI > 30) using univariate and multivariate analysis. Results: A total of 2072 subjects were identified between the ages of 13-19 years. LVH was significantly more prevalent in obese subjects (47/166 [28.3%] vs. nonobese subjects (99/1612 [6.1%]) with a P-value of < 0.001. Using multivariate analysis adjusting for age, gender and blood pressure, obesity remained strongly associated with the presence of LVH (OR 4.51, CI: 2.83-7.19, P < 0.001). Elevated SBP and DBP were also strongly associated with obesity. SBP > 140 was present in 38% of obese subjects (54/142) versus 12.7% of nonobese subjects (172/1, 353). DBP > 90 was present in 10.6% of obese subjects (15/141) of versus 3.1% of nonobese subjects (42/1352). After adjustment for age, gender and LVH, obesity remained independently associated with HTN (for SBP > 140, OR 2.24, CI: 1.46-3.45, P < 0.001, and for DBP > 90, OR 2.10, CI: 1.063-4.17, P = 0.03). Conclusion: Obese adolescents have a significantly higher prevalence of HTN and LVH. Our analysis suggests a direct negative effect of obesity on cardiovascular function starting early in teenage years. (Echocardiography 2011;28:150-153).
引用
收藏
页码:150 / 153
页数:4
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