Cascade-release dendrimers liberate all end groups upon a single triggering event in the dendritic core

被引：190

作者：

de Groot, FMH ^{[1
]}

Albrecht, C

Koekkoek, R

Beusker, PH

Scheeren, HW

机构：

[1] Syntarga BV, NL-6525 ED Nijmegen, Netherlands

[2] Univ Nijmegen, Dept Organ Chem, NL-6525 ED Nijmegen, Netherlands

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 37期

关键词：

dendrimers; drug delivery; fragmentation; multiple release; prodrugs;

D O I：

10.1002/anie.200351942

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A single triggering event in the core of a dendrimer composed of two or more generations of multiple-release monomeric building blocks can induce the release of all end groups at the termini of the dendrimer (see schematic representation). Such multiple-release systems could find application, for example, in the field of (targeted) drug delivery, where a disease- or organ-specific activation event could trigger simultaneous release of multiple biologically active molecules.

引用

收藏

页码：4490 / 4494

页数：5

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