The genetics of signal transduction and the effect of smoking on intrauterine growth

被引：8

作者：

Bottini, E

Gloria-Bottini, F

La Torre, M

Lucarini, N

机构：

[1] Univ Roma Tor Vergata, Sch Med, Chair Prevent & Social Pediat, Rome, Italy

[2] St Massimo Hosp, Dept Pediat, USSL, Penne, Italy

[3] Univ Camerino, Genet Lab, Sch Sci, Camerino, Italy

来源：

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY | 2001年 / 30卷 / 02期

关键词：

cLMWPTP; ACP1; smoke; birthweight;

D O I：

10.1093/ije/30.2.400

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We have studied cytosolic low molecular weight phosphotyrosine phosphatase (cLMWPTP or ACP1) in 364 healthy puerperae from the population of Penne, in 155 diabetic puerperae from the population of Rome and in 349 consecutive normal newborn infants from the population of Rome. The data from these independent samples point to a protective role of maternal ACP1 genotypes with medium-high activity against intrauterine growth retardation caused by smoking.

引用

收藏

页码：400 / 402

页数：3

相关论文

共 10 条

[1] INTRAUTERINE GROWTH - ASSOCIATION WITH ACID-PHOSPHATASE GENETIC-POLYMORPHISM [J].

AMANTE, A ;

GLORIABOTTINI, F ;

BOTTINI, E .

JOURNAL OF PERINATAL MEDICINE, 1990, 18 (04) :275-282

[2]

[Anonymous], 1981, Statistical Tables

[3] STUDIES OF IN-VITRO EFFECTS OF OXIDIZED GLUTATHIONE AND ACETYLPHENYLHYDRAZINE ON ACID PHOSPHATASES OF HUMAN RED BLOOD CELL - EXPERIMENTAL MODEL FOR INVESTIGATION OF HEMOLYTIC DRUG ACTION AT MOLECULAR LEVEL [J].

BOTTINI, E ;

MODIANO, G ;

SANTOLAM.C ;

FILIPPI, G ;

BUSINCO, L .

CLINICA CHIMICA ACTA, 1971, 31 (01) :243-&

[4] ACP1 AND HUMAN ADAPTABILITY .1. ASSOCIATION WITH COMMON DISEASES - A CASE-CONTROL STUDY [J].

BOTTINI, E ;

GLORIABOTTINI, F ;

BORGIANI, P .

HUMAN GENETICS, 1995, 96 (06) :629-637

[5] Phosphotyrosine protein phosphatases and diabetic pregnancy: An association between low molecular weight acid phosphatase and degree of glycemic control [J].

GloriaBottini, F ;

Gerlini, G ;

Lucarini, N ;

Borgiani, P ;

Amante, A ;

LaTorre, M ;

Antonacci, E ;

Bottini, E .

EXPERIENTIA, 1996, 52 (04) :340-343

[6] Impact of oxidative stress on signal transduction control by phosphotyrosine phosphatases [J].

Krejsa, CM ;

Schieven, GL .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1998, 106 :1179-1184

[7]

LOW PS, 1987, J BIOL CHEM, V262, P4592

[8] Polynitroxylated hemoglobin-based oxygen carrier: Inhibition of free radical-induced microcirculatory dysfunction [J].

Saetzler, RK ;

Arfors, KE ;

Tuma, RF ;

Vasthare, U ;

Ma, L ;

Hsia, CJC ;

Lehr, HA .

FREE RADICAL BIOLOGY AND MEDICINE, 1999, 27 (1-2) :1-6

[9] QUANTITATIVE DIFFERENCES + GENE DOSAGE IN HUMAN RED CELL ACID PHOSPHATASE POLYMORPHISM [J].

SPENCER, N ;

HOPKINSON, DA ;

HARRIS, H .

NATURE, 1964, 201 (491) :299-&

[10]

*SPSS INC, SPSS PC PLUS VERSION