Mitochondria, oxygen free radicals, and apoptosis

被引：248

作者：

Raha, S

Robinson, BH

机构：

[1] Hosp Sick Children, Res Inst, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Dept Biochem & Mol Biol, Toronto, ON, Canada

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 2001年 / 106卷 / 01期

关键词：

mitochondria; reactive oxygen species (ROS); oxygen free radicals; apoptosis; aging;

D O I：

10.1002/ajmg.1398

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Reactive oxygen species (ROS) generated by mitochondria are produced as by-products of normal oxidative metabolism. The fate of these species is governed by a number of factors that vary from tissue to tissue in mammals and may be involved in the pathogenesis of disease. Reactive oxygen species are also invoked as agents that are important in the processes which become active in cells undergoing apoptosis. Integration of knowledge surrounding these different aspects of ROS generation is difficult and reveals considerable gaps in our understanding. (C) 2001 Wiley-Liss. Inc.

引用

页码：62 / 70

页数：9

共 57 条

[1] Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production
Arsenijevic, D
Onuma, H
Pecqueur, C
Raimbault, S
Manning, BS
Miroux, B
Couplan, E
Alves-Guerra, MC
Goubern, M
Surwit, R
Bouillaud, F
Richard, D
Collins, S
Ricquier, D
[J]. NATURE GENETICS, 2000, 26 (04) : 435 - 439
[2] The role of p53 in tumour suppression: lessons from mouse models
Attardi, LD
Jacks, T
[J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 1999, 55 (01) : 48 - 63
[3] AN ANALYSIS OF THE ROLE OF COENZYME-Q IN FREE-RADICAL GENERATION AND AS AN ANTIOXIDANT
BEYER, RE
[J]. BIOCHEMISTRY AND CELL BIOLOGY, 1992, 70 (06) : 390 - 403
[4] Bogdanov MB, 1998, J NEUROCHEM, V71, P1321
[5] Boveris A, 1977, Adv Exp Med Biol, V78, P67
[6] Proton-translocation by membrane-bound NADH:ubiquinone-oxidoreductase (complex I) through redox-gated ligand conduction
Brandt, U
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1997, 1318 (1-2): : 79 - 91
[7] The 49-kDa subunit of NADH-ubiquinone oxidoreductase (Complex I) is involved in the binding of piericidin and rotenone, two quinone-related inhibitors
Darrouzet, E
Issartel, JP
Lunardi, J
Dupuis, A
[J]. FEBS LETTERS, 1998, 431 (01): : 34 - 38
[8] Mechanisms of p53-mediated apoptosis
Ding, HF
Fisher, DE
[J]. CRITICAL REVIEWS IN ONCOGENESIS, 1998, 9 (01): : 83 - 98
[9] Generation of superoxide anion by mitochondria and impairment of their functions during anoxia and reoxygenation in vitro
Du, G
Mouithys-Mickalad, A
Sluse, FE
[J]. FREE RADICAL BIOLOGY AND MEDICINE, 1998, 25 (09) : 1066 - 1074
[10] PHOTOLABELING OF A MITOCHONDRIALLY ENCODED SUBUNIT OF NADH DEHYDROGENASE WITH [H-3] DIHYDROROTENONE
EARLEY, FGP
PATEL, SD
RAGAN, CI
ATTARDI, G
[J]. FEBS LETTERS, 1987, 219 (01) : 108 - 113

← 1 2 3 4 5 6 →