Gap junctions in the ovary: Expression, localization and function

被引：134

作者：

Gershon, Eran ^{[1
]}

Plaks, Vicki ^{[1
]}

Dekel, Nava ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Regulat Biol, IL-76100 Rehovot, Israel

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2008年 / 282卷 / 1-2期

关键词：

gap junction; connexin; 43; ovary; folliculogenesis; oocyte maturation;

D O I：

10.1016/j.mce.2007.11.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Gap junctions that allow the direct communication between cytoplasmic compartments of neighboring cells are present in a variety of tissues and organs and play pivotal roles in a wide range of physiological processes. In the ovary, gap junctions consist mainly of connexin (Cx) 43 and Cx37, and their indispensable role in regulating folliculogenesis and oogenesis is well established. The ovarian Cx43 is regulated by gonadotropins at the transcriptional, translational and post-translational levels whereas the regulation of the ovarian Cx37 is yet unknown. In addition to their involvement in normal ovarian functions, gap junction proteins, particularly Cx43, seem to act as cancer suppressors. A summary of our present knowledge regarding gap junctional communication (GJC) and the ovarian gap junction proteins in normally developing ovaries and under pathological conditions is presented in this review. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：18 / 25

页数：8

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