Heparin-Like Macromolecules for the Modification of Anticoagulant Biomaterials

被引：101

作者：

Ran, Fen ^{[1
,2
,3
]}

Nie, Shengqiang ^{[1
,2
]}

Li, Jie ^{[3
]}

Su, Baihai ^{[1
,2
]}

Sun, Shudong ^{[1
,2
]}

Zhao, Changsheng ^{[1
,2
]}

机构：

[1] Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China

[2] Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China

[3] Lanzhou Univ Technol, State Key Lab Gansu Adv Nonferrous Met Mat, Lanzhou 730050, Peoples R China

来源：

MACROMOLECULAR BIOSCIENCE | 2012年 / 12卷 / 01期

基金：

中国国家自然科学基金;

关键词：

anticoagulant biomaterials; biocompatibility; blood compatibility; heparin-like macromolecules; polyethersulfone membranes; BLOOD COMPATIBILITY; PROTEIN ADSORPTION; PHOSPHOLIPID POLYMER; MODIFIED POLYSULFONE; POLYETHERSULFONE; MEMBRANE; IMPROVEMENT; ACID;

D O I：

10.1002/mabi.201100249

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A heparin-like structured macromolecule (HLSM) is synthesized by RAFT polymerization using carboxyl-terminated trithiocarbonate as the RAFT agent. The HLSM can be directly blended with PES in DMAC to prepare flat-sheet membrane by means of a liquidliquid phase separation technique. The synthesized polymeric material retard blood clotting and the modified membrane exhibits good anticoagulant ability due to the existence of the important functional groups ?SO3H, ?COOH and ?OH. The anionic groups on the membrane surface may bind coagulation factors and thus improve anticoagulant ability. The results indicate that the HLSM has potential to improve the anticoagulant properties of biomaterials and to be applied in blood purification including hemodialysis and bioartificial liver supports.

引用

页码：116 / 125

页数：10

共 38 条

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