Possible mechanisms of valproate in migraine prophylaxis

被引：104

作者：

Cutrer, FM ^{[1
]}

Limmroth, V ^{[1
]}

Moskowitz, MA ^{[1
]}

机构：

[1] MASSACHUSETTS GEN HOSP,DEPT NEUROSURG,CHARLESTOWN,MA 02129

来源：

CEPHALALGIA | 1997年 / 17卷 / 02期

关键词：

D O I：

10.1046/j.1468-2982.1997.1702093.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Valproate has been shown to be an effective prophylactic treatment in migraine. Investigation of the mechanism of its antimigraine action is difficult due to the broad range of its biochemical effects and the complex nature of migraine pathophysiology. Valproate increases brain GABA levels and, in doing so, may suppress migraine-related events in the cortex, perivascular parasympathetics or trigeminal nucleus caudalis. There is experimental evidence that it suppresses neurogenic inflammation and directly attenuates nociceptive neurotransmission. In addition, valproate reportedly alters levels of excitatory and inhibitory neurotransmitters and exerts direct effects on neuronal membranes in vitro. Valproate's observed effect may ultimately result from a combination of actions at different loci.

引用

页码：93 / 100

页数：8

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