Molecular cloning and DNA sequencing of the Staphylococcus aureus UDP-N-acetylmuramyl tripeptide synthetase (murE) gene, essential for the optimal expression of methicillin resistance

被引：21

作者：

Ludovice, AM

Wu, SW

De Lencastre, H ^{[1
]}

机构：

[1] Rockefeller Univ, Microbiol Lab, New York, NY 10021 USA

[2] Univ Nova Lisboa, Inst Tecnol Quim & Biol, Mol Genet Unit, P-2780 Oeiras, Portugal

[3] Univ Nova Lisboa, Fac Ciencias & Tecnol, P-2825 Monte De Caparica, Portugal

[4] Karolinska Hosp, Dept Lab Med, Div Clin Microbiol, S-17176 Stockholm, Sweden

来源：

MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE | 1998年 / 4卷 / 02期

关键词：

D O I：

10.1089/mdr.1998.4.85

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The Tn551 insertion in mutant RUSA235 of a highly methicillin resistant Staphylococcus aureus strain results in drastic reduction in the level of methicillin resistance and abnormalities, both in the composition of the peptidoglycan and of the cell wall precursor pool. Cloning and sequencing of the inactivated gene indicates that it is the murE gene of Staphylococcus aureus.

引用

页码：85 / 90

页数：6

共 49 条

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