Human placental NAD(P)H oxidase: Solubilization and properties

被引：22

作者：

Manes, C ^{[1
]}

机构：

[1] Univ San Diego, Dept Biol, San Diego, CA 92110 USA

来源：

PLACENTA | 2001年 / 22卷 / 01期

关键词：

D O I：

10.1053/plac.2000.0589

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The NAD(P)H oxidase in the syncytiotrophoblast of the term human placenta, which had previously been identified only by cytochemical methods, has been solubilized and a number of its biochemical properties have been defined. It is a protein composed of a 58 kDa and a 33 kDa subunit, with properties that clearly distinguish it from the respirator burst oxidase of transient neutrophils and macrophages. The enzyme activity is constitutive in the trophoblast and is a source of reactive oxygen species (ROS) at the fetal-maternal interface. (C) 2001 Harcourt Publishers Ltd.

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页码：58 / 63

页数：6

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