The voltage-sensor structure in a voltage-gated channel

被引：38

作者：

Bezanilla, F ^{[1
]}

机构：

[1] Univ Calif Los Angeles, D Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, D Geffen Sch Med, Dept Anesthesiol, Los Angeles, CA 90095 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2005年 / 30卷 / 04期

关键词：

D O I：

10.1016/j.tibs.2005.02.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A recent electron paramagnetic resonance study of KvAP, a prokaryotic voltage-gated channel, in its lipid native environment has revealed the location of the transmembrane segments, the connecting loops and the relative position of the voltage-sensing charges. The results confirm that the previously reported crystal structure does not represent a native conformation and give us structural constraints that will help in determining the molecular structure of the voltage sensor.

引用

页码：166 / 168

页数：3

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