The voltage-sensor structure in a voltage-gated channel

被引:38
作者
Bezanilla, F [1 ]
机构
[1] Univ Calif Los Angeles, D Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, D Geffen Sch Med, Dept Anesthesiol, Los Angeles, CA 90095 USA
关键词
D O I
10.1016/j.tibs.2005.02.006
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A recent electron paramagnetic resonance study of KvAP, a prokaryotic voltage-gated channel, in its lipid native environment has revealed the location of the transmembrane segments, the connecting loops and the relative position of the voltage-sensing charges. The results confirm that the previously reported crystal structure does not represent a native conformation and give us structural constraints that will help in determining the molecular structure of the voltage sensor.
引用
收藏
页码:166 / 168
页数:3
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