The voltage-sensor structure in a voltage-gated channel

被引：39

作者：

Bezanilla, F ^{[1
]}

机构：

[1] Univ Calif Los Angeles, D Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, D Geffen Sch Med, Dept Anesthesiol, Los Angeles, CA 90095 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2005年 / 30卷 / 04期

关键词：

D O I：

10.1016/j.tibs.2005.02.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A recent electron paramagnetic resonance study of KvAP, a prokaryotic voltage-gated channel, in its lipid native environment has revealed the location of the transmembrane segments, the connecting loops and the relative position of the voltage-sensing charges. The results confirm that the previously reported crystal structure does not represent a native conformation and give us structural constraints that will help in determining the molecular structure of the voltage sensor.

引用

页码：166 / 168

页数：3

共 21 条

[1] Contribution of the S4 segment to gating charge in the Shaker K+ channel [J].

Aggarwal, SK ;

MacKinnon, R .

NEURON, 1996, 16 (06) :1169-1177

[2] CURRENTS RELATED TO MOVEMENT OF GATING PARTICLES OF SODIUM CHANNELS [J].

ARMSTRONG, CM ;

BEZANILLA, F .

NATURE, 1973, 242 (5398) :459-461

[3] A fluorometric approach to local electric field measurements in a voltage-gated ion channel [J].

Asamoah, OK ;

Wuskell, JP ;

Loew, LM ;

Bezanilla, F .

NEURON, 2003, 37 (01) :85-97

[4] Three transmembrane conformations and sequence-dependent displacement of the S4 domain in shaker K+ channel gating [J].

Baker, OS ;

Larsson, HP ;

Mannuzzu, LM ;

Isacoff, EY .

NEURON, 1998, 20 (06) :1283-1294

[5] DISTRIBUTION AND KINETICS OF MEMBRANE DIELECTRIC POLARIZATION .1. LONG-TERM INACTIVATION OF GATING CURRENTS [J].

BEZANILLA, F ;

TAYLOR, RE ;

FERNANDEZ, JM .

JOURNAL OF GENERAL PHYSIOLOGY, 1982, 79 (01) :21-40

[6] Molecular architecture of the KvAP voltage-dependent K+ channel in a lipid bilayer [J].

Cuello, LG ;

Cortes, DM ;

Perozo, E .

SCIENCE, 2004, 306 (5695) :491-495

[7] The structure of the potassium channel:: Molecular basis of K+ conduction and selectivity [J].

Doyle, DA ;

Cabral, JM ;

Pfuetzner, RA ;

Kuo, AL ;

Gulbis, JM ;

Cohen, SL ;

Chait, BT ;

MacKinnon, R .

SCIENCE, 1998, 280 (5360) :69-77

[8] A QUANTITATIVE DESCRIPTION OF MEMBRANE CURRENT AND ITS APPLICATION TO CONDUCTION AND EXCITATION IN NERVE [J].

HODGKIN, AL ;

HUXLEY, AF .

JOURNAL OF PHYSIOLOGY-LONDON, 1952, 117 (04) :500-544

[9] The principle of gating charge movement in a voltage-dependent K+ channel [J].

Jiang, YX ;

Ruta, V ;

Chen, JY ;

Lee, A ;

MacKinnon, R .

NATURE, 2003, 423 (6935) :42-48

[10] X-ray structure of a voltage-dependent K+ channel [J].

Jiang, YX ;

Lee, A ;

Chen, JY ;

Ruta, V ;

Cadene, M ;

Chait, BT ;

MacKinnon, R .

NATURE, 2003, 423 (6935) :33-41

← 1 2 3 →