Apolipoprotein E ε4 allele frequency is increased in Parkinson's disease only with co-existing Alzheimer pathology

被引:31
作者
Mattila, PM
Koskela, T
Röyttä, M
Lehtimäki, T
Pirttila, TA
Ilveskoski, E
Karhunen, P
Rinne, JO [1 ]
机构
[1] Univ Turku, Dept Neurol, FIN-20520 Turku, Finland
[2] Univ Turku, Dept Pathol, FIN-20520 Turku, Finland
[3] Tampere Univ Hosp, Dept Clin Chem, Res Lab Atherosclerosis, FIN-33521 Tampere, Finland
[4] Univ Tampere, Sch Med, Dept Biochem Med, FIN-33101 Tampere, Finland
[5] Tampere Univ Hosp, Dept Neurol, Tampere, Finland
[6] Univ Tampere, Sch Med, Dept Forens Med, FIN-33101 Tampere, Finland
关键词
apolipoprotein E; genotype; Parkinson's disease; Alzheimer's disease; polymerase chain reaction;
D O I
10.1007/s004010050913
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We determined the apolipoprotein E (apoE) genotype in clinically diagnosed and neuropathologically verified cases of Parkinson's disease (PD) (n = 45), with or without Alzheimer (AD)-type changes, and compared the apoE genotype with that in healthy age-matched controls (n = 59). The PD cases were divided into two groups according to the CERAD criteria: "O + A", with no or only uncertain histological findings of AD, and "B + C" with histological findings suggestive or indicative of AD. DNA was isolated from frozen brain samples, and the apoE genotypes were determined using polymerase chain reaction amplification and subsequent restriction analysis by HhaI enzyme. The frequency of the apo epsilon 4 allele (29.4%) was significantly increased in the B + C group. The odds ratio for an apoe4 allele in the B + C group was 2.5 as compared to controls (95% confidence interval, 1.2-5.2). In the O + A group, the frequency of apo epsilon 4 allele (13.6%) was similar to that in controls (14.4%) and the risk of an apo epsilon 4 allele was not increased (odds ratio 0.94). The PD cases with an apoe4 allele had a greater number of cortical (P = 0.02) but not nigral Lewy bodies than those without an apoe4 allele (P = 0.57). The results show that neuropathologically verified PD as such is not associated with increased apoe4 allele frequency.
引用
收藏
页码:417 / 420
页数:4
相关论文
共 27 条
[1]  
Agresti A., 1990, CATEGORICAL DATA ANA, P558
[2]   APOLIPOPROTEIN-E GENE IN PARKINSONS-DISEASE WITH OR WITHOUT DEMENTIA [J].
ARAI, H ;
MURAMATSU, T ;
HIGUCHI, S ;
SASAKI, H ;
TROJANOWSKI, JQ .
LANCET, 1994, 344 (8926) :889-889
[3]   LEWY BODIES CONTAIN BETA-AMYLOID PRECURSOR PROTEINS OF ALZHEIMERS-DISEASE [J].
ARAI, H ;
LEE, VMY ;
HILL, WD ;
GREENBERG, BD ;
TROJANOWSKI, JQ .
BRAIN RESEARCH, 1992, 585 (1-2) :386-390
[4]   APOLIPOPROTEIN-E GENES IN LEWY BODY AND PARKINSONS-DISEASE [J].
BENJAMIN, R ;
LEAKE, A ;
EDWARDSON, JA ;
MCKEITH, IG ;
INCE, PG ;
PERRY, RH ;
MORRIS, CM .
LANCET, 1994, 343 (8912) :1565-1565
[5]   The apolipoprotein E epsilon 4 allele in Parkinson's disease with Alzheimer lesions [J].
Egensperger, R ;
Bancher, C ;
Kosel, S ;
Jellinger, K ;
Mehraein, P ;
Graeber, MB .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 224 (02) :484-486
[6]   GENOTYPING AND SEQUENCE-ANALYSIS OF APOLIPOPROTEIN-E ISOFORMS [J].
EMI, M ;
WU, LL ;
ROBERTSON, MA ;
MYERS, RL ;
HEGELE, RA ;
WILLIAMS, RR ;
WHITE, R ;
LALOUEL, JM .
GENOMICS, 1988, 3 (04) :373-379
[7]   THE APOLIPOPROTEIN-E ALLELE EPSILON-4 IS OVERREPRESENTED IN PATIENTS WITH THE LEWY BODY VARIANT OF ALZHEIMERS-DISEASE [J].
GALASKO, D ;
SAITOH, T ;
XIA, Y ;
THAL, LJ ;
KATZMAN, R ;
HILL, LR ;
HANSEN, L .
NEUROLOGY, 1994, 44 (10) :1950-1951
[8]   ALZHEIMERS-DISEASE WITH AND WITHOUT COEXISTING PARKINSONS-DISEASE CHANGES - APOLIPOPROTEIN-E GENOTYPE AND NEUROPATHOLOGIC CORRELATES [J].
GEARING, M ;
SCHNEIDER, JA ;
REBECK, GW ;
HYMAN, BT ;
MIRRA, SS .
NEUROLOGY, 1995, 45 (11) :1985-1990
[9]  
HARRINGTON CR, 1994, AM J PATHOL, V145, P1472
[10]  
HIXSON JE, 1990, J LIPID RES, V31, P545