We test the climate effects of changes in the tropical ocean by imposing three different patterns of tropical SSTs in ice age general circulation model simulations that include water source tracers and water isotope tracers. The continental air temperature and hydrological cycle response in these simulations is substantial and should be directly comparable to the paleoclimatic record. With tropical cooling imposed, there is a strong temperature response in mid- to high-latitudes resulting from changes in sea ice and disturbance of the planetary waves; the results suggest that tropical/subtropical ocean cooling leads to significant dynamical and radiative feedbacks that might amplify ice age cycles, The isotopes in precipitation generally follow the temperature response at higher latitudes, but regional delta O-18/air temperature scaling factors differ greatly among the experiments. In low-latitudes, continental surface temperatures decrease congruently with the adjacent SSTs in the cooling experiments. Assuming CLIMAP SSTs, O-18/O-16 ratios in low-latitude precipitation show no change from modern values. However, the experiments with additional cooling of SSTs produce much lower tropical continental delta O-18 values, and these low values result primarily from an enhanced recycling of continental moisture (as marine evaporation is reduced). The water isotopes are especially sensitive to continental aridity, suggesting that they represent an effective tracer of the extent of tropical cooling and drying. Only one of the tropical cooling simulations produces generalized low-latitude aridity. These results demonstrate that the geographic pattern of cooling is most critical for promoting much drier continents, and they underscore the need for accurate reconstructions of SST gradients in the ice age ocean.