The first silver-catalyzed three-component coupling of aldehyde, alkyne, and amine

被引:461
作者
Wei, CM
Li, ZG
Li, CJ [1 ]
机构
[1] Tulane Univ, Dept Chem, New Orleans, LA 70118 USA
[2] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada
关键词
D O I
10.1021/ol035781y
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Silver iodide catalyzed the three-component coupling of aldehyde, alkyne, and amines to generate propargylic amines with high efficiency in water. The silver-catalyzed reaction is especially effective for reactions involving aliphatic aldehyde. No additional cocatalyst or activator is required.
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页码:4473 / 4475
页数:3
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