Inhibition of Cryptosporidium infection in mice treated with a cyclodextrin inclusion complex with diloxanide furoate

被引：10

作者：

Hermida, JAC

Ares-Mazás, ME

Reyes, LN

Espinar, FO

Méndez, JB

机构：

[1] Univ Santiago de Compostela, Fac Pharm, Dept Microbiol & Parasitol, Parasitol Lab, Santiago De Compostela 15706, La Coruna, Spain

[2] Univ Santiago de Compostela, Fac Pharm, Dept Pharm & Pharmaceut Technol, Santiago De Compostela 15706, La Coruna, Spain

来源：

PARASITOLOGY RESEARCH | 2001年 / 87卷 / 06期

关键词：

D O I：

10.1007/s004360000359

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The efficacies of diloxanide furoate, beta -cyclodextrin and a cyclodextrin inclusion complex against Cryptosporidium parvum were evaluated in a suckling murine model. Efficacy was established by numbers of oocysts recovered from the intestinal tract of mice on day 7 postinfection. The level of infection in treated mice was significantly lower than in control mice and, surprisingly, the most efficacious treatment was beta -cyclodextrin, an excipient used in pharmaceutical technology.

引用

页码：449 / 452

页数：4

共 12 条

[1] Dicationic furans inhibit development of Cryptosporidium parvum in HSD/ICR suckling Swiss mice [J].

Blagburn, BL ;

Drain, KL ;

Land, TM ;

Moore, PH ;

Kinard, RG ;

Lindsay, DS ;

Kumar, A ;

Shi, JX ;

Boykin, DW ;

Tidwell, RR .

JOURNAL OF PARASITOLOGY, 1998, 84 (04) :851-856

[2] HUMAN CRYPTOSPORIDIOSIS IN IMMUNOCOMPETENT AND IMMUNODEFICIENT PERSONS - STUDIES OF AN OUTBREAK AND EXPERIMENTAL TRANSMISSION [J].

CURRENT, WL ;

REESE, NC ;

ERNST, JV ;

BAILEY, WS ;

HEYMAN, MB ;

WEINSTEIN, WM .

NEW ENGLAND JOURNAL OF MEDICINE, 1983, 308 (21) :1252-1257

[3] A review of the importance of cryptosporidiosis in farm animals [J].

de Graaf, DC ;

Vanopdenbosch, E ;

Ortega-Mora, LM ;

Abbassi, H ;

Peeters, JE .

INTERNATIONAL JOURNAL FOR PARASITOLOGY, 1999, 29 (08) :1269-1287

[4]

Duchene D., 1991, NEW TRENDS CYCLODEXT

[5] GLYCOSIDE ANTIBIOTICS ALONE AND COMBINED WITH TETRACYCLINES FOR PROPHYLAXIS OF EXPERIMENTAL CRYPTOSPORIDIOSIS IN NEONATAL BALB/C MICE [J].

FAYER, R ;

ELLIS, W .

JOURNAL OF PARASITOLOGY, 1993, 79 (04) :553-558

[6]

Fayer R, 1997, CRYPTOSPORIDIUM CRYP

[7] EFFECT OF ULTRAVIOLET DISINFECTION OF DRINKING-WATER ON THE VIABILITY OF CRYPTOSPORIDIUM-PARVUM OOCYSTS [J].

LORENZOLORENZO, MJ ;

ARESMAZAS, ME ;

DEMATURANA, IVM ;

DURANOREIRO, D .

JOURNAL OF PARASITOLOGY, 1993, 79 (01) :67-70

[8] CRYPTOSPORIDIUM AND CRYPTOSPORIDIOSIS IN MAN AND ANIMALS [J].

ODONOGHUE, PJ .

INTERNATIONAL JOURNAL FOR PARASITOLOGY, 1995, 25 (02) :139-195

[9] EFFECT OF DISINFECTION OF DRINKING-WATER WITH OZONE OR CHLORINE DIOXIDE ON SURVIVAL OF CRYPTOSPORIDIUM-PARVUM OOCYSTS [J].

PEETERS, JE ;

MAZAS, EA ;

MASSCHELEIN, WJ ;

DEMATURANA, IVM ;

DEBACKER, E .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1989, 55 (06) :1519-1522

[10]

STERLING CR, 1993, PARASITIC PROTOZOA, P59

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